======= SEC24C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC24C
  * **<color #00a2e8>Official Name</color>**: SEC24 homolog C, COPII coat complex component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9632|9632]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P53992|P53992]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC24C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC24C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607185|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296, PubMed:20427317). Plays a central role in cargo selection within the COPII complex and together with SEC24D may have a different specificity compared to SEC24A and SEC24B (PubMed:17499046, PubMed:20427317, PubMed:18843296). May more specifically package GPI-anchored proteins through the cargo receptor TMED10 (PubMed:20427317). May also be specific for IxM motif-containing cargos like the SNAREs GOSR2 and STX5 (PubMed:18843296). {ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec23 BS|
|Gelsolin|
|Sec23 helical|
|zf-Sec23 Sec24|
|Sec23 trunk|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|COPII-coated vesicle cargo loading|
|COPII vesicle coat|
|vesicle cargo loading|
|ER to Golgi transport vesicle membrane|
|COPII vesicle coating|
|vesicle targeting, rough ER to cis-Golgi|
|SNARE binding|
|vesicle coating|
|COPII-coated vesicle budding|
|vesicle targeting, to, from or within Golgi|
|Golgi vesicle budding|
|localization within membrane|
|vesicle targeting|
|vesicle budding from membrane|
|antigen processing and presentation of peptide antigen via MHC class I|
|antigen processing and presentation of exogenous peptide antigen via MHC class II|
|antigen processing and presentation of peptide antigen via MHC class II|
|antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|
|establishment of vesicle localization|
|antigen processing and presentation of exogenous peptide antigen|
|antigen processing and presentation of exogenous antigen|
|vesicle localization|
|antigen processing and presentation of peptide antigen|
|endoplasmic reticulum to Golgi vesicle-mediated transport|
|antigen processing and presentation|
|vesicle organization|
|establishment of organelle localization|
|Golgi vesicle transport|
|organelle localization|
|Golgi membrane|
|zinc ion binding|
|membrane organization|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-2.79|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.48|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.91|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-1.77|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|2.06|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.17|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.26|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.28|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.35|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.588|
|[[:human genes:s:sec23b|SEC23B]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15969
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC24C Expression in NALM6 Cells: 6.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>