======= SEC61G =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC61G
  * **<color #00a2e8>Official Name</color>**: SEC61 translocon subunit gamma
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23480|23480]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P60059|P60059]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC61G&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC61G|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Necessary for protein translocation in the endoplasmic reticulum. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SecE|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|P-P-bond-hydrolysis-driven protein transmembrane transporter activity|
|protein transmembrane transporter activity|
|protein transmembrane transport|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to organelle|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-1.88|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.82|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.8|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.79|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.75|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.85|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.91|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.25|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hspd1|HSPD1]]|0.539|
|[[:human genes:r:rnmt|RNMT]]|0.525|
|[[:human genes:t:triap1|TRIAP1]]|0.523|
|[[:human genes:g:gmppb|GMPPB]]|0.512|
|[[:human genes:t:thg1l|THG1L]]|0.502|
|[[:human genes:p:pmm2|PMM2]]|0.5|
|[[:human genes:n:nae1|NAE1]]|0.498|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.492|
|[[:human genes:a:apaf1|APAF1]]|0.481|
|[[:human genes:a:adsl|ADSL]]|0.474|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.459|
|[[:human genes:u:uap1|UAP1]]|0.458|
|[[:human genes:b:bap1|BAP1]]|0.456|
|[[:human genes:p:pik3r4|PIK3R4]]|0.454|
|[[:human genes:t:trnt1|TRNT1]]|0.45|
|[[:human genes:h:hccs|HCCS]]|0.449|
|[[:human genes:r:rptor|RPTOR]]|0.445|
|[[:human genes:c:cycs|CYCS]]|0.443|
|[[:human genes:a:atp2a2|ATP2A2]]|0.443|
|[[:human genes:e:eif4e|EIF4E]]|0.439|
|[[:human genes:r:romo1|ROMO1]]|0.438|
|[[:human genes:c:csnk2b|CSNK2B]]|0.437|
|[[:human genes:v:vrk1|VRK1]]|0.437|
|[[:human genes:g:gfpt1|GFPT1]]|0.435|
|[[:human genes:d:dad1|DAD1]]|0.434|
|[[:human genes:s:spcs2|SPCS2]]|0.433|
|[[:human genes:a:atxn10|ATXN10]]|0.433|
|[[:human genes:m:meaf6|MEAF6]]|0.432|
|[[:human genes:d:dpagt1|DPAGT1]]|0.431|
|[[:human genes:u:utp23|UTP23]]|0.428|
|[[:human genes:a:aars|AARS]]|0.427|
|[[:human genes:e:eny2|ENY2]]|0.426|
|[[:human genes:d:dohh|DOHH]]|0.425|
|[[:human genes:r:rpp21|RPP21]]|0.423|
|[[:human genes:d:dpf2|DPF2]]|0.422|
|[[:human genes:s:srp14|SRP14]]|0.422|
|[[:human genes:a:alg13|ALG13]]|0.416|
|[[:human genes:b:bak1|BAK1]]|0.416|
|[[:human genes:a:alg1|ALG1]]|0.416|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.416|
|[[:human genes:p:plaa|PLAA]]|0.415|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.415|
|[[:human genes:r:rtcb|RTCB]]|0.415|
|[[:human genes:a:alg5|ALG5]]|0.414|
|[[:human genes:r:rpe|RPE]]|0.413|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.413|
|[[:human genes:c:casp9|CASP9]]|0.412|
|[[:human genes:c:chchd4|CHCHD4]]|0.411|
|[[:human genes:z:znhit1|ZNHIT1]]|0.41|
|[[:human genes:s:ssb|SSB]]|0.41|
|[[:human genes:h:haus8|HAUS8]]|0.407|
|[[:human genes:v:vezt|VEZT]]|0.406|
|[[:human genes:m:mtor|MTOR]]|0.405|
|[[:human genes:t:telo2|TELO2]]|0.403|
|[[:human genes:p:pisd|PISD]]|0.403|
|[[:human genes:r:rpn1|RPN1]]|0.403|
|[[:human genes:c:cbfb|CBFB]]|0.401|
|[[:human genes:t:tsen54|TSEN54]]|0.401|
|[[:human genes:e:eif1ax|EIF1AX]]|0.401|
|[[:human genes:p:ppcs|PPCS]]|0.401|
|[[:human genes:t:trmt5|TRMT5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 254/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|11/28|
|blood|10/28|
|bone|8/26|
|breast|15/33|
|central nervous system|17/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|11/21|
|liver|11/20|
|lung|27/75|
|lymphocyte|5/16|
|ovary|10/26|
|pancreas|1/24|
|peripheral nervous system|8/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|6/9|
|thyroid|0/2|
|upper aerodigestive|6/22|
|urinary tract|11/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3961
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC61G Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>