======= SEC62 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEC62
  * **<color #00a2e8>Official Name</color>**: SEC62 homolog, preprotein translocation factor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7095|7095]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99442|Q99442]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEC62&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEC62|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602173|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for preprotein translocation. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sec62|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|posttranslational protein targeting to membrane, translocation|
|posttranslational protein targeting to endoplasmic reticulum membrane|
|intracellular protein transmembrane transport|
|protein transmembrane transport|
|rough endoplasmic reticulum|
|cotranslational protein targeting to membrane|
|integral component of endoplasmic reticulum membrane|
|protein targeting to ER|
|establishment of protein localization to endoplasmic reticulum|
|protein localization to endoplasmic reticulum|
|protein targeting to membrane|
|signaling receptor activity|
|establishment of protein localization to membrane|
|protein targeting|
|establishment of protein localization to organelle|
|protein localization to membrane|
|protein localization to organelle|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|endoplasmic reticulum|
|transmembrane transport|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp152|SGC2043 10μM R03 exp152]]|-2.31|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-2.17|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.97|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.94|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.9|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.84|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.74|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.74|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.75|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.77|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.77|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.78|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.79|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.79|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.85|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.85|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|1.88|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.9|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.9|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.12|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.12|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.18|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.19|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.22|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.4|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.5|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.51|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.76|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.8|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|3.12|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|3.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:alg6|ALG6]]|0.607|
|[[:human genes:s:sec63|SEC63]]|0.565|
|[[:human genes:d:dhrsx|DHRSX]]|0.556|
|[[:human genes:p:pmm2|PMM2]]|0.528|
|[[:human genes:r:romo1|ROMO1]]|0.527|
|[[:human genes:u:uap1|UAP1]]|0.527|
|[[:human genes:m:mbtps2|MBTPS2]]|0.527|
|[[:human genes:a:alg5|ALG5]]|0.526|
|[[:human genes:a:alg9|ALG9]]|0.524|
|[[:human genes:t:triap1|TRIAP1]]|0.52|
|[[:human genes:s:ssb|SSB]]|0.516|
|[[:human genes:m:manf|MANF]]|0.513|
|[[:human genes:u:ube2g2|UBE2G2]]|0.511|
|[[:human genes:d:dnajc3|DNAJC3]]|0.507|
|[[:human genes:d:dnajb11|DNAJB11]]|0.505|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.505|
|[[:human genes:d:dpagt1|DPAGT1]]|0.505|
|[[:human genes:d:dpm1|DPM1]]|0.503|
|[[:human genes:t:trmt10a|TRMT10A]]|0.501|
|[[:human genes:t:thg1l|THG1L]]|0.499|
|[[:human genes:a:alg8|ALG8]]|0.499|
|[[:human genes:a:alg1|ALG1]]|0.497|
|[[:human genes:k:kdsr|KDSR]]|0.497|
|[[:human genes:s:srp14|SRP14]]|0.494|
|[[:human genes:d:dpm3|DPM3]]|0.493|
|[[:human genes:u:ufc1|UFC1]]|0.492|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.488|
|[[:human genes:s:stt3a|STT3A]]|0.487|
|[[:human genes:s:srd5a3|SRD5A3]]|0.486|
|[[:human genes:u:uba5|UBA5]]|0.485|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.48|
|[[:human genes:a:alg13|ALG13]]|0.479|
|[[:human genes:a:atxn10|ATXN10]]|0.478|
|[[:human genes:u:ube2j1|UBE2J1]]|0.475|
|[[:human genes:a:alg3|ALG3]]|0.472|
|[[:human genes:u:urm1|URM1]]|0.471|
|[[:human genes:t:tmed10|TMED10]]|0.466|
|[[:human genes:p:pggt1b|PGGT1B]]|0.466|
|[[:human genes:r:rptor|RPTOR]]|0.464|
|[[:human genes:p:pgm3|PGM3]]|0.463|
|[[:human genes:r:rpe|RPE]]|0.458|
|[[:human genes:t:trmt61a|TRMT61A]]|0.457|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.454|
|[[:human genes:g:gfpt1|GFPT1]]|0.454|
|[[:human genes:a:atg9a|ATG9A]]|0.453|
|[[:human genes:c:crls1|CRLS1]]|0.453|
|[[:human genes:c:c1orf27|C1orf27]]|0.452|
|[[:human genes:m:mpdu1|MPDU1]]|0.451|
|[[:human genes:c:cbfb|CBFB]]|0.451|
|[[:human genes:m:mrps6|MRPS6]]|0.448|
|[[:human genes:y:yars2|YARS2]]|0.446|
|[[:human genes:d:dnlz|DNLZ]]|0.446|
|[[:human genes:d:dolk|DOLK]]|0.446|
|[[:human genes:g:gmppb|GMPPB]]|0.445|
|[[:human genes:m:mbtps1|MBTPS1]]|0.445|
|[[:human genes:t:timm13|TIMM13]]|0.444|
|[[:human genes:p:pdap1|PDAP1]]|0.443|
|[[:human genes:a:atp5o|ATP5O]]|0.442|
|[[:human genes:d:dohh|DOHH]]|0.44|
|[[:human genes:e:eef1e1|EEF1E1]]|0.435|
|[[:human genes:a:atp5a1|ATP5A1]]|0.433|
|[[:human genes:r:rft1|RFT1]]|0.432|
|[[:human genes:p:pars2|PARS2]]|0.431|
|[[:human genes:r:rtcb|RTCB]]|0.431|
|[[:human genes:c:chchd4|CHCHD4]]|0.428|
|[[:human genes:e:eny2|ENY2]]|0.424|
|[[:human genes:p:parl|PARL]]|0.424|
|[[:human genes:a:atp5d|ATP5D]]|0.424|
|[[:human genes:a:atp2a2|ATP2A2]]|0.423|
|[[:human genes:m:mrps11|MRPS11]]|0.423|
|[[:human genes:a:adsl|ADSL]]|0.422|
|[[:human genes:b:bcs1l|BCS1L]]|0.421|
|[[:human genes:e:exoc4|EXOC4]]|0.421|
|[[:human genes:t:ttc4|TTC4]]|0.419|
|[[:human genes:t:taz|TAZ]]|0.417|
|[[:human genes:s:slc25a26|SLC25A26]]|0.416|
|[[:human genes:t:timm8b|TIMM8B]]|0.414|
|[[:human genes:r:rpp21|RPP21]]|0.413|
|[[:human genes:a:atp5j|ATP5J]]|0.412|
|[[:human genes:t:tmem41b|TMEM41B]]|0.412|
|[[:human genes:e:elac2|ELAC2]]|0.412|
|[[:human genes:r:rnmt|RNMT]]|0.411|
|[[:human genes:e:elp3|ELP3]]|0.411|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.41|
|[[:human genes:t:tsen54|TSEN54]]|0.409|
|[[:human genes:l:lsm11|LSM11]]|0.409|
|[[:human genes:m:mocs3|MOCS3]]|0.409|
|[[:human genes:v:vezt|VEZT]]|0.407|
|[[:human genes:d:dap3|DAP3]]|0.407|
|[[:human genes:m:mrps18a|MRPS18A]]|0.407|
|[[:human genes:s:ssbp2|SSBP2]]|0.407|
|[[:human genes:p:pelo|PELO]]|0.406|
|[[:human genes:u:ufsp2|UFSP2]]|0.406|
|[[:human genes:a:alg2|ALG2]]|0.405|
|[[:human genes:a:atp5c1|ATP5C1]]|0.403|
|[[:human genes:m:mlst8|MLST8]]|0.403|
|[[:human genes:t:trnt1|TRNT1]]|0.402|
|[[:human genes:p:pik3c3|PIK3C3]]|0.402|
|[[:human genes:a:atp5b|ATP5B]]|0.402|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.401|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 7/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|1/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3288
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEC62 Expression in NALM6 Cells: 7.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>