======= SELE =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SELE
  * **<color #00a2e8>Official Name</color>**: selectin E
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6401|6401]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16581|P16581]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SELE&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SELE|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/131210|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis. {ECO:0000269|PubMed:1689848, ECO:0000269|PubMed:28011641}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|EGF|
|Sushi|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oligosaccharide binding|
|sialic acid binding|
|leukocyte migration involved in inflammatory response|
|phospholipase binding|
|leukocyte tethering or rolling|
|cortical cytoskeleton|
|leukocyte adhesion to vascular endothelial cell|
|positive regulation of receptor internalization|
|activation of phospholipase C activity|
|cellular extravasation|
|positive regulation of phospholipase C activity|
|heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules|
|regulation of phospholipase C activity|
|leukocyte cell-cell adhesion|
|positive regulation of receptor-mediated endocytosis|
|regulation of receptor internalization|
|clathrin-coated pit|
|positive regulation of phospholipase activity|
|regulation of phospholipase activity|
|positive regulation of lipase activity|
|caveola|
|regulation of lipase activity|
|positive regulation of endocytosis|
|regulation of receptor-mediated endocytosis|
|transmembrane signaling receptor activity|
|calcium-mediated signaling|
|response to interleukin-1|
|regulation of endocytosis|
|membrane raft|
|cell-cell adhesion via plasma-membrane adhesion molecules|
|response to tumor necrosis factor|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|regulation of inflammatory response|
|second-messenger-mediated signaling|
|leukocyte migration|
|inflammatory response|
|cell-cell adhesion|
|regulation of vesicle-mediated transport|
|actin filament-based process|
|response to bacterium|
|perinuclear region of cytoplasm|
|regulation of defense response|
|positive regulation of hydrolase activity|
|response to lipid|
|cell adhesion|
|biological adhesion|
|cell migration|
|positive regulation of transport|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of cellular component organization|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10680
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SELE Expression in NALM6 Cells: -4.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>