======= SELK =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SELENOK
  * **<color #00a2e8>Official Name</color>**: selenoprotein K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=58515|58515]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y6D0|Q9Y6D0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SELK&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SELK|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607916|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum- associated degradation (ERAD) of soluble glycosylated proteins (PubMed:22016385). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low- density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function (PubMed:25368151). Plays a role in protection of cells from ER stress-induced apoptosis (PubMed:20692228). Protects cells from oxidative stress when overexpressed in cardiomyocytes (PubMed:16962588). {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000269|PubMed:16962588, ECO:0000269|PubMed:20692228, ECO:0000269|PubMed:22016385, ECO:0000269|PubMed:25368151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2763|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|respiratory burst after phagocytosis|
|foam cell differentiation|
|respiratory burst involved in defense response|
|macrophage derived foam cell differentiation|
|positive regulation of monocyte chemotactic protein-1 production|
|positive regulation of chemokine secretion|
|regulation of chemokine secretion|
|regulation of monocyte chemotactic protein-1 production|
|respiratory burst|
|endoplasmic reticulum calcium ion homeostasis|
|positive regulation of defense response to virus by host|
|positive regulation of T cell migration|
|positive regulation of interleukin-6 secretion|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|protein palmitoylation|
|positive regulation of lymphocyte migration|
|regulation of defense response to virus by host|
|regulation of T cell migration|
|positive regulation of chemokine production|
|regulation of lymphocyte migration|
|regulation of defense response to virus|
|regulation of chemokine production|
|positive regulation of tumor necrosis factor production|
|protein lipidation|
|positive regulation of tumor necrosis factor superfamily cytokine production|
|lipoprotein biosynthetic process|
|positive regulation of interleukin-6 production|
|positive regulation of T cell proliferation|
|regulation of calcium-mediated signaling|
|lipoprotein metabolic process|
|positive regulation of leukocyte migration|
|positive regulation of lymphocyte proliferation|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|positive regulation of cytokine secretion|
|regulation of interleukin-6 production|
|regulation of tumor necrosis factor production|
|intrinsic apoptotic signaling pathway|
|regulation of tumor necrosis factor superfamily cytokine production|
|regulation of T cell proliferation|
|protein acylation|
|regulation of leukocyte migration|
|positive regulation of T cell activation|
|regulation of cytokine secretion|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|calcium ion transport|
|positive regulation of cell-cell adhesion|
|response to endoplasmic reticulum stress|
|positive regulation of protein secretion|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|divalent metal ion transport|
|regulation of leukocyte cell-cell adhesion|
|divalent inorganic cation transport|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|response to oxidative stress|
|regulation of cell-cell adhesion|
|positive regulation of secretion by cell|
|positive regulation of leukocyte activation|
|positive regulation of cell adhesion|
|positive regulation of cell activation|
|positive regulation of protein transport|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of peptide secretion|
|positive regulation of cell migration|
|regulation of lymphocyte activation|
|positive regulation of cell motility|
|regulation of response to biotic stimulus|
|positive regulation of cellular component movement|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|regulation of leukocyte activation|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|regulation of cell adhesion|
|regulation of cytokine production|
|cation homeostasis|
|regulation of protein transport|
|inorganic ion homeostasis|
|regulation of peptide transport|
|cellular chemical homeostasis|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of multi-organism process|
|ion homeostasis|
|regulation of secretion|
|cation transport|
|regulation of cell migration|
|cellular homeostasis|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|apoptotic process|
|endoplasmic reticulum membrane|
|regulation of locomotion|
|Golgi apparatus|
|positive regulation of transport|
|regulation of cellular component movement|
|endoplasmic reticulum|
|regulation of protein localization|
|programmed cell death|
|identical protein binding|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|chemical homeostasis|
|positive regulation of immune system process|
|defense response|
|ion transport|
|organonitrogen compound biosynthetic process|
|regulation of response to stress|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of intracellular signal transduction|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp495|IWR1 50μM R08 exp495]]|-1.74|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10728
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SELK Expression in NALM6 Cells: 4.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>