======= SEMA5A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA5A
  * **<color #00a2e8>Official Name</color>**: semaphorin 5A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9037|9037]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13591|Q13591]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA5A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA5A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609297|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Bifunctional axonal guidance cue regulated by sulfated proteoglycans; attractive effects result from interactions with heparan sulfate proteoglycans (HSPGs), while the inhibitory effects depend on interactions with chondroitin sulfate proteoglycans (CSPGs) (By similarity). Ligand for receptor PLXNB3. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. May promote angiogenesis by increasing endothelial cell proliferation and migration and inhibiting apoptosis. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:19850054, ECO:0000269|PubMed:20696765, ECO:0000269|PubMed:21706053}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
|TSP 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal clustering|
|chondroitin sulfate proteoglycan binding|
|blood vessel endothelial cell proliferation involved in sprouting angiogenesis|
|syndecan binding|
|positive regulation of axon extension involved in axon guidance|
|positive regulation of axon guidance|
|positive regulation of actin filament depolymerization|
|positive regulation of endothelial cell chemotaxis|
|heparan sulfate proteoglycan binding|
|positive regulation of protein depolymerization|
|regulation of endothelial cell chemotaxis|
|semaphorin receptor binding|
|endothelial cell proliferation|
|axonal fasciculation|
|neuron projection fasciculation|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|negative regulation of axon guidance|
|negative regulation of endothelial cell apoptotic process|
|regulation of axon extension involved in axon guidance|
|axon extension|
|positive regulation of protein complex disassembly|
|semaphorin-plexin signaling pathway|
|negative regulation of epithelial cell apoptotic process|
|negative regulation of axon extension|
|positive regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|positive chemotaxis|
|neuron recognition|
|regulation of endothelial cell apoptotic process|
|regulation of actin filament depolymerization|
|neural crest cell migration|
|sprouting angiogenesis|
|negative regulation of chemotaxis|
|neuron projection extension|
|negative regulation of axonogenesis|
|diencephalon development|
|regulation of epithelial cell apoptotic process|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|regulation of protein depolymerization|
|positive regulation of axonogenesis|
|epithelial cell proliferation|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|positive regulation of endothelial cell proliferation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|positive regulation of endothelial cell migration|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|regulation of protein complex disassembly|
|developmental growth involved in morphogenesis|
|regulation of endothelial cell proliferation|
|positive regulation of chemotaxis|
|positive regulation of epithelial cell migration|
|positive regulation of canonical Wnt signaling pathway|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|regulation of endothelial cell migration|
|stem cell differentiation|
|positive regulation of cell growth|
|positive regulation of angiogenesis|
|positive regulation of protein kinase B signaling|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|positive regulation of Wnt signaling pathway|
|negative regulation of cell projection organization|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|positive regulation of vasculature development|
|negative regulation of cell growth|
|regulation of actin filament length|
|regulation of axonogenesis|
|positive regulation of epithelial cell proliferation|
|positive regulation of supramolecular fiber organization|
|cell chemotaxis|
|regulation of chemotaxis|
|regulation of epithelial cell migration|
|regulation of protein kinase B signaling|
|positive regulation of cytoskeleton organization|
|mesenchyme development|
|negative regulation of neuron differentiation|
|cell recognition|
|negative regulation of growth|
|positive regulation of growth|
|regulation of actin filament organization|
|neuron projection guidance|
|negative regulation of cell adhesion|
|positive regulation of neuron projection development|
|regulation of canonical Wnt signaling pathway|
|regulation of angiogenesis|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of epithelial cell proliferation|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|regulation of Wnt signaling pathway|
|negative regulation of response to external stimulus|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|regulation of actin filament-based process|
|developmental growth|
|growth|
|blood vessel morphogenesis|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|blood vessel development|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|vasculature development|
|regulation of anatomical structure size|
|cell part morphogenesis|
|cardiovascular system development|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|positive regulation of locomotion|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|positive regulation of response to external stimulus|
|positive regulation of organelle organization|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cell adhesion|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|cell-cell signaling|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4995
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA5A Expression in NALM6 Cells: 1.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>