======= SEMA6D =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA6D
  * **<color #00a2e8>Official Name</color>**: semaphorin 6D
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80031|80031]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NFY4|Q8NFY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA6D&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA6D|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609295|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sema|
|PSI|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|neuropilin binding|
|negative regulation of smooth muscle cell migration|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|ventricular system development|
|chemorepellent activity|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|positive regulation of smooth muscle cell migration|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|neural crest cell migration|
|negative regulation of chemotaxis|
|regulation of smooth muscle cell migration|
|negative regulation of axonogenesis|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|neural crest cell differentiation|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|negative regulation of neuron projection development|
|mesenchymal cell differentiation|
|stem cell differentiation|
|ameboidal-type cell migration|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|regulation of chemotaxis|
|mesenchyme development|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|negative regulation of cell migration|
|negative regulation of cell motility|
|negative regulation of neurogenesis|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|negative regulation of response to external stimulus|
|regulation of cellular component size|
|regulation of cell growth|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of cell migration|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|brain development|
|head development|
|regulation of neurogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|negative regulation of multicellular organismal process|
|locomotion|
|integral component of plasma membrane|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|tissue development|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6909
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA6D Expression in NALM6 Cells: 1.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>