======= SEMA7A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEMA7A
  * **<color #00a2e8>Official Name</color>**: semaphorin 7A (John Milton Hagen blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8482|8482]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75326|O75326]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEMA7A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEMA7A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607961|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the semaphorin family of proteins. The encoded preproprotein is proteolytically processed to generate the mature glycosylphosphatidylinositol (GPI)-anchored membrane glycoprotein. The encoded protein is found on activated lymphocytes and erythrocytes and may be involved in immunomodulatory and neuronal processes. The encoded protein carries the John Milton Hagen (JMH) blood group antigens. Mutations in this gene may be associated with reduced bone mineral density (BMD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PSI|
|Sema|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of macrophage cytokine production|
|regulation of macrophage cytokine production|
|neuropilin binding|
|positive regulation of myeloid leukocyte cytokine production involved in immune response|
|semaphorin receptor binding|
|negative regulation of axon extension involved in axon guidance|
|chemorepellent activity|
|negative regulation of axon guidance|
|regulation of axon extension involved in axon guidance|
|olfactory lobe development|
|axon extension|
|semaphorin-plexin signaling pathway|
|negative regulation of axon extension|
|positive regulation of axon extension|
|regulation of axon guidance|
|negative chemotaxis|
|positive regulation of cytokine production involved in immune response|
|neural crest cell migration|
|negative regulation of chemotaxis|
|neuron projection extension|
|negative regulation of axonogenesis|
|neural crest cell development|
|mesenchymal cell development|
|stem cell development|
|regulation of cytokine production involved in immune response|
|positive regulation of axonogenesis|
|developmental cell growth|
|neural crest cell differentiation|
|cell growth|
|integrin-mediated signaling pathway|
|positive regulation of production of molecular mediator of immune response|
|regulation of axon extension|
|negative regulation of cell morphogenesis involved in differentiation|
|anchored component of membrane|
|negative regulation of developmental growth|
|regulation of extent of cell growth|
|developmental growth involved in morphogenesis|
|osteoblast differentiation|
|integrin binding|
|regulation of production of molecular mediator of immune response|
|negative regulation of neuron projection development|
|positive regulation of cell morphogenesis involved in differentiation|
|mesenchymal cell differentiation|
|stem cell differentiation|
|positive regulation of cell growth|
|positive regulation of developmental growth|
|ameboidal-type cell migration|
|negative regulation of cell projection organization|
|regulation of cell size|
|negative regulation of cell growth|
|regulation of axonogenesis|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of chemotaxis|
|positive regulation of immune effector process|
|mesenchyme development|
|negative regulation of neuron differentiation|
|negative regulation of growth|
|telencephalon development|
|positive regulation of growth|
|ossification|
|positive regulation of neuron projection development|
|negative regulation of neurogenesis|
|regulation of ERK1 and ERK2 cascade|
|regulation of cell morphogenesis involved in differentiation|
|negative regulation of cellular component movement|
|negative regulation of nervous system development|
|negative regulation of locomotion|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|positive regulation of neuron differentiation|
|axonogenesis|
|regulation of cellular component size|
|positive regulation of cell projection organization|
|forebrain development|
|developmental growth|
|growth|
|external side of plasma membrane|
|axon development|
|regulation of cell growth|
|cell morphogenesis involved in neuron differentiation|
|positive regulation of cytokine production|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|inflammatory response|
|positive regulation of cell migration|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of cytokine production|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|regulation of defense response|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|positive regulation of immune response|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|regulation of response to external stimulus|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|locomotion|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of protein phosphorylation|
|regulation of response to stress|
|generation of neurons|
|movement of cell or subcellular component|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|-1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15338
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.78 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEMA7A Expression in NALM6 Cells: 0.78'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>