======= SEPHS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SEPHS2
  * **<color #00a2e8>Official Name</color>**: selenophosphate synthetase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22928|22928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99611|Q99611]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SEPHS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SEPHS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606218|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Synthesizes selenophosphate from selenide and ATP.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AIRS|
|AIRS C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|selenocysteine biosynthetic process|
|tRNA seleno-modification|
|selenide, water dikinase activity|
|selenocysteine metabolic process|
|selenium compound metabolic process|
|serine family amino acid biosynthetic process|
|serine family amino acid metabolic process|
|alpha-amino acid biosynthetic process|
|cellular amino acid biosynthetic process|
|tRNA modification|
|tRNA processing|
|RNA modification|
|tRNA metabolic process|
|alpha-amino acid metabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|ncRNA processing|
|cellular component|
|ncRNA metabolic process|
|small molecule biosynthetic process|
|RNA processing|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|phosphorylation|
|organonitrogen compound biosynthetic process|
|ATP binding|
|RNA metabolic process|
|small molecule metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.31|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-3.26|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-3|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.79|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.79|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.75|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.66|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.61|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-2.54|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-2.5|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.49|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.46|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.46|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.44|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.41|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.34|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-2.28|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|-2.24|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.22|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|-2.2|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.18|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.17|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-2.17|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-2.16|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-2.16|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.15|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.12|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|-2.11|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.11|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-2.08|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-2.08|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.06|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-2.05|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.04|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|-2.01|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-1.99|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.98|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|-1.98|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.98|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.97|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.97|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.96|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.95|
|[[:results:exp275|Citral 75μM R06 exp275]]|-1.95|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|-1.94|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|-1.94|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.93|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-1.93|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.91|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|-1.9|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.9|
|[[:results:exp237|NN-Diethyl-meta-toluamide 100μM R05 exp237]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.89|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-1.88|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.87|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-1.87|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.86|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.86|
|[[:results:exp405|Tenofovir 10μM R07 exp405]]|-1.86|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.84|
|[[:results:exp345|Cidofovir 10μM R07 exp345]]|-1.83|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.81|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.79|
|[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|-1.78|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.76|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.76|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.75|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.75|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.74|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.73|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.72|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-1.72|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.71|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.71|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-1.71|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pstk|PSTK]]|0.576|
|[[:human genes:e:eefsec|EEFSEC]]|0.55|
|[[:human genes:g:gpx4|GPX4]]|0.472|
|[[:human genes:r:rrm1|RRM1]]|0.461|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 277/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|22/28|
|bone|12/26|
|breast|10/33|
|central nervous system|16/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|1/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|12/21|
|liver|8/20|
|lung|28/75|
|lymphocyte|12/16|
|ovary|9/26|
|pancreas|8/24|
|peripheral nervous system|8/16|
|plasma cell|9/15|
|prostate|0/1|
|skin|10/24|
|soft tissue|5/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|10/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1305
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SEPHS2 Expression in NALM6 Cells: 5.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>