======= SERPINB9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINB9
  * **<color #00a2e8>Official Name</color>**: serpin family B member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5272|5272]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50453|P50453]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINB9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINB9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601799|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Granzyme B inhibitor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation by symbiont of host programmed cell death|
|protection from natural killer cell mediated cytotoxicity|
|negative regulation by symbiont of host apoptotic process|
|modulation by organism of apoptotic process in other organism involved in symbiotic interaction|
|modulation of programmed cell death in other organism|
|modulation of programmed cell death in other organism involved in symbiotic interaction|
|modulation of apoptotic process in other organism|
|modulation by symbiont of host apoptotic process|
|modulation by symbiont of host programmed cell death|
|negative regulation of natural killer cell mediated cytotoxicity|
|cellular response to estrogen stimulus|
|negative regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated cytotoxicity|
|mast cell mediated immunity|
|negative regulation of cell killing|
|cysteine-type endopeptidase inhibitor activity involved in apoptotic process|
|modulation by symbiont of host cellular process|
|negative regulation of lymphocyte mediated immunity|
|modification by symbiont of host morphology or physiology|
|regulation of natural killer cell mediated cytotoxicity|
|regulation of natural killer cell mediated immunity|
|negative regulation of leukocyte mediated immunity|
|negative regulation of innate immune response|
|response to estrogen|
|regulation of leukocyte mediated cytotoxicity|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cysteine-type endopeptidase activity|
|negative regulation of response to biotic stimulus|
|serine-type endopeptidase inhibitor activity|
|regulation of cell killing|
|protease binding|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|negative regulation of immune effector process|
|negative regulation of immune response|
|regulation of lymphocyte mediated immunity|
|modification of morphology or physiology of other organism|
|interaction with host|
|regulation of leukocyte mediated immunity|
|negative regulation of defense response|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of multi-organism process|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|myeloid leukocyte mediated immunity|
|regulation of response to biotic stimulus|
|response to bacterium|
|regulation of proteolysis|
|regulation of defense response|
|leukocyte mediated immunity|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|interspecies interaction between organisms|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|apoptotic process|
|Golgi apparatus|
|negative regulation of cell death|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|regulation of immune response|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|regulation of response to stress|
|regulation of apoptotic process|
|regulation of programmed cell death|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|immune response|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11730
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINB9 Expression in NALM6 Cells: 5.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>