======= SERPINE2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINE2
  * **<color #00a2e8>Official Name</color>**: serpin family E member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5270|5270]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07093|P07093]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINE2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINE2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/177010|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine protease inhibitor with activity toward thrombin, trypsin, and urokinase. Promotes neurite extension by inhibiting thrombin. Binds heparin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mating plug formation|
|seminal vesicle epithelium development|
|post-mating behavior|
|seminal vesicle development|
|negative regulation of plasminogen activation|
|extrinsic component of external side of plasma membrane|
|cerebellar granular layer morphogenesis|
|negative regulation of platelet aggregation|
|positive regulation of astrocyte differentiation|
|insemination|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|regulation of timing of cell differentiation|
|cerebellar granular layer development|
|regulation of plasminogen activation|
|platelet alpha granule|
|regulation of development, heterochronic|
|copulation|
|negative regulation of homotypic cell-cell adhesion|
|negative regulation of sodium ion transport|
|regulation of platelet aggregation|
|negative regulation of platelet activation|
|mating behavior|
|glycosaminoglycan binding|
|regulation of homotypic cell-cell adhesion|
|innervation|
|regulation of astrocyte differentiation|
|reproductive behavior|
|detection of mechanical stimulus involved in sensory perception|
|negative regulation of smoothened signaling pathway|
|cerebellar cortex morphogenesis|
|regulation of platelet activation|
|negative regulation of protein processing|
|mating|
|negative regulation of protein maturation|
|secretory granule organization|
|cerebellum morphogenesis|
|hindbrain morphogenesis|
|positive regulation of glial cell differentiation|
|detection of mechanical stimulus|
|cerebellar cortex development|
|long-term synaptic potentiation|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|extracellular vesicle|
|regulation of protein processing|
|regulation of protein maturation|
|positive regulation of gliogenesis|
|regulation of synaptic transmission, glutamatergic|
|regulation of glial cell differentiation|
|negative regulation of wound healing|
|neuromuscular junction|
|regulation of smoothened signaling pathway|
|regulation of blood coagulation|
|nerve development|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|regulation of sodium ion transport|
|serine-type endopeptidase inhibitor activity|
|cerebellum development|
|metencephalon development|
|regulation of gliogenesis|
|detection of external stimulus|
|regulation of phosphatidylinositol 3-kinase signaling|
|detection of abiotic stimulus|
|negative regulation of protein catabolic process|
|regulation of wound healing|
|negative regulation of ion transport|
|hindbrain development|
|positive regulation of synaptic transmission|
|regulation of response to wounding|
|sensory perception of mechanical stimulus|
|heparin binding|
|negative regulation of cell-cell adhesion|
|negative regulation of cell growth|
|regulation of synaptic plasticity|
|negative regulation of cell activation|
|multi-multicellular organism process|
|response to mechanical stimulus|
|negative regulation of growth|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell adhesion|
|blood coagulation|
|coagulation|
|hemostasis|
|vesicle organization|
|negative regulation of catabolic process|
|signaling receptor binding|
|negative regulation of proteolysis|
|negative regulation of response to external stimulus|
|collagen-containing extracellular matrix|
|regulation of protein catabolic process|
|regulation of metal ion transport|
|regulation of cell-cell adhesion|
|gland development|
|regulation of cell growth|
|regulation of endopeptidase activity|
|endomembrane system organization|
|reproductive structure development|
|reproductive system development|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|wound healing|
|negative regulation of transport|
|regulation of body fluid levels|
|negative regulation of intracellular signal transduction|
|positive regulation of nervous system development|
|positive regulation of cell development|
|detection of stimulus involved in sensory perception|
|behavior|
|response to wounding|
|regulation of cell activation|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|detection of stimulus|
|regulation of ion transport|
|regulation of proteolysis|
|brain development|
|head development|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|tube development|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|sensory perception|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|multi-organism reproductive process|
|regulation of catabolic process|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|generation of neurons|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of transport|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINE2 Expression in NALM6 Cells: 5.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>