======= SERPINF1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPINF1
  * **<color #00a2e8>Official Name</color>**: serpin family F member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=5176|5176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P36955|P36955]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPINF1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPINF1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/172860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI. [provided by RefSeq, Aug 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular response to cobalt ion|
|negative regulation of epithelial cell proliferation involved in prostate gland development|
|axon hillock|
|short-term memory|
|response to cobalt ion|
|regulation of epithelial cell proliferation involved in prostate gland development|
|response to acidic pH|
|cellular response to dexamethasone stimulus|
|response to arsenic-containing substance|
|response to dexamethasone|
|response to pH|
|negative regulation of endothelial cell migration|
|cellular response to glucocorticoid stimulus|
|negative regulation of reproductive process|
|cellular response to corticosteroid stimulus|
|negative regulation of epithelial cell migration|
|ovulation cycle|
|cellular response to retinoic acid|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|cellular response to monosaccharide stimulus|
|cellular response to carbohydrate stimulus|
|cellular glucose homeostasis|
|basement membrane|
|cellular response to ketone|
|response to antineoplastic agent|
|serine-type endopeptidase inhibitor activity|
|melanosome|
|negative regulation of angiogenesis|
|negative regulation of blood vessel morphogenesis|
|response to retinoic acid|
|negative regulation of vasculature development|
|memory|
|negative regulation of epithelial cell proliferation|
|negative regulation of inflammatory response|
|response to glucose|
|retina development in camera-type eye|
|response to hexose|
|response to glucocorticoid|
|response to monosaccharide|
|regulation of endothelial cell migration|
|regulation of reproductive process|
|response to corticosteroid|
|response to carbohydrate|
|glucose homeostasis|
|carbohydrate homeostasis|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|cellular response to metal ion|
|response to ketone|
|negative regulation of neuron death|
|negative regulation of defense response|
|cellular response to acid chemical|
|regulation of epithelial cell migration|
|cellular response to inorganic substance|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|negative regulation of cell migration|
|learning or memory|
|kidney development|
|negative regulation of cell motility|
|rhythmic process|
|aging|
|positive regulation of neuron projection development|
|renal system development|
|regulation of angiogenesis|
|cognition|
|response to xenobiotic stimulus|
|negative regulation of cellular component movement|
|regulation of neuron death|
|camera-type eye development|
|urogenital system development|
|regulation of vasculature development|
|negative regulation of locomotion|
|response to steroid hormone|
|regulation of epithelial cell proliferation|
|regulation of inflammatory response|
|response to acid chemical|
|negative regulation of proteolysis|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|sensory system development|
|positive regulation of neuron differentiation|
|response to metal ion|
|positive regulation of cell projection organization|
|cellular response to drug|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|positive regulation of neurogenesis|
|regulation of neuron projection development|
|cellular response to lipid|
|response to inorganic substance|
|positive regulation of nervous system development|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|sensory organ development|
|behavior|
|cellular response to hormone stimulus|
|regulation of neuron differentiation|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|perinuclear region of cytoplasm|
|regulation of cell projection organization|
|regulation of proteolysis|
|cellular chemical homeostasis|
|regulation of defense response|
|negative regulation of catalytic activity|
|regulation of neurogenesis|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|regulation of cell migration|
|response to lipid|
|cellular homeostasis|
|response to hormone|
|regulation of cell motility|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|positive regulation of cell differentiation|
|regulation of locomotion|
|negative regulation of cell death|
|regulation of cellular component movement|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|response to abiotic stimulus|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|cellular response to endogenous stimulus|
|regulation of hydrolase activity|
|positive regulation of developmental process|
|nervous system process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|homeostatic process|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|extracellular region|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8145
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPINF1 Expression in NALM6 Cells: 3.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>