======= SERPING1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SERPING1
  * **<color #00a2e8>Official Name</color>**: serpin family G member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=710|710]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05155|P05155]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SERPING1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SERPING1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/606860|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Serpin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of complement activation, lectin pathway|
|negative regulation of complement activation, lectin pathway|
|negative regulation of complement activation|
|negative regulation of humoral immune response|
|blood coagulation, intrinsic pathway|
|fibrinolysis|
|blood coagulation, fibrin clot formation|
|protein activation cascade|
|negative regulation of blood coagulation|
|negative regulation of hemostasis|
|negative regulation of coagulation|
|negative regulation of innate immune response|
|platelet alpha granule lumen|
|negative regulation of wound healing|
|regulation of blood coagulation|
|regulation of hemostasis|
|regulation of coagulation|
|negative regulation of response to wounding|
|negative regulation of response to biotic stimulus|
|serine-type endopeptidase inhibitor activity|
|regulation of complement activation|
|negative regulation of immune effector process|
|platelet degranulation|
|regulation of humoral immune response|
|regulation of wound healing|
|blood microparticle|
|negative regulation of immune response|
|complement activation, classical pathway|
|regulation of response to wounding|
|humoral immune response mediated by circulating immunoglobulin|
|complement activation|
|immunoglobulin mediated immune response|
|negative regulation of defense response|
|B cell mediated immunity|
|negative regulation of multi-organism process|
|negative regulation of endopeptidase activity|
|negative regulation of peptidase activity|
|lymphocyte mediated immunity|
|aging|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|blood coagulation|
|coagulation|
|hemostasis|
|humoral immune response|
|negative regulation of proteolysis|
|collagen-containing extracellular matrix|
|negative regulation of response to external stimulus|
|blood circulation|
|circulatory system process|
|regulation of endopeptidase activity|
|negative regulation of immune system process|
|regulation of peptidase activity|
|regulation of innate immune response|
|negative regulation of hydrolase activity|
|regulation of immune effector process|
|wound healing|
|regulation of body fluid levels|
|regulation of response to biotic stimulus|
|response to wounding|
|adaptive immune response|
|activation of immune response|
|regulated exocytosis|
|regulation of proteolysis|
|regulation of defense response|
|leukocyte mediated immunity|
|innate immune response|
|regulation of multi-organism process|
|negative regulation of catalytic activity|
|exocytosis|
|positive regulation of immune response|
|defense response to other organism|
|secretion by cell|
|negative regulation of cellular protein metabolic process|
|export from cell|
|immune effector process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|extracellular space|
|negative regulation of response to stimulus|
|regulation of immune system process|
|immune response|
|extracellular region|
|vesicle-mediated transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3269
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SERPING1 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>