======= SESTD1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SESTD1
  * **<color #00a2e8>Official Name</color>**: SEC14 and spectrin domain containing 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=91404|91404]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VW0|Q86VW0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SESTD1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SESTD1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621011|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as the primary docking protein directing membrane turnover and assembly of the transient receptor potential channels TRPC4 and TRPC5. Binds phospholipids such as phosphatidylinositol monophosphates, phosphatidylinositol diphosphates (PIP2s) and phosphatidic acid, but not less polar lipids including phosphatidylcholine, phosphatidylserine, and phosphatidylinositol. The binding to PIP2s is calcium dependent. Might be involved in the plasma membrane localization of CTNNB1. {ECO:0000269|PubMed:20164195}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|regulation of calcium ion transmembrane transport via high voltage-gated calcium channel|
|1-phosphatidylinositol binding|
|phosphatidylinositol-5-phosphate binding|
|phosphatidic acid binding|
|calcium channel complex|
|phosphatidylcholine binding|
|phosphatidylinositol-3,5-bisphosphate binding|
|phosphatidylinositol-3,4-bisphosphate binding|
|phosphatidylinositol-4-phosphate binding|
|negative regulation of calcium ion transmembrane transport|
|phosphatidylinositol-3-phosphate binding|
|intermediate filament cytoskeleton|
|phosphatidylserine binding|
|negative regulation of calcium ion transport|
|phosphatidylinositol-4,5-bisphosphate binding|
|negative regulation of cation transmembrane transport|
|negative regulation of ion transmembrane transport|
|negative regulation of transmembrane transport|
|negative regulation of ion transport|
|regulation of calcium ion transmembrane transport|
|regulation of calcium ion transport|
|regulation of cation transmembrane transport|
|regulation of metal ion transport|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of transmembrane transport|
|regulation of ion transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.21|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|-2.04|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.82|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|-1.7|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.74|
|[[:results:exp149|SB203580 25μM R03 exp149]]|1.97|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.57|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.458|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14755
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SESTD1 Expression in NALM6 Cells: 5.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>