======= SETD6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SETD6
  * **<color #00a2e8>Official Name</color>**: SET domain containing 6, protein lysine methyltransferase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=79918|79918]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TBK2|Q8TBK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SETD6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SETD6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616424|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein-lysine N-methyltransferase. Monomethylates 'Lys- 310' of the RELA subunit of NF-kappa-B complex, leading to down- regulate NF-kappa-B transcription factor activity (PubMed:21131967). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). {ECO:0000250|UniProtKB:Q9CWY3, ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:23324626}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rubis-subs-bind|
|SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|peptidyl-lysine monomethylation|
|protein-lysine N-methyltransferase activity|
|NF-kappaB binding|
|histone lysine methylation|
|negative regulation of NF-kappaB transcription factor activity|
|peptidyl-lysine methylation|
|histone methylation|
|protein alkylation|
|protein methylation|
|stem cell population maintenance|
|maintenance of cell number|
|stem cell differentiation|
|negative regulation of DNA-binding transcription factor activity|
|macromolecule methylation|
|methylation|
|peptidyl-lysine modification|
|regulation of inflammatory response|
|histone modification|
|covalent chromatin modification|
|regulation of DNA-binding transcription factor activity|
|chromatin organization|
|regulation of defense response|
|peptidyl-amino acid modification|
|chromosome organization|
|regulation of response to external stimulus|
|negative regulation of molecular function|
|regulation of response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-4.6|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.11|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.01|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8609
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SETD6 Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>