======= SETMAR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SETMAR
  * **<color #00a2e8>Official Name</color>**: SET domain and mariner transposase fusion gene
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6419|6419]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q53H47|Q53H47]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SETMAR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SETMAR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609834|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Protein derived from the fusion of a methylase with the transposase of an Hsmar1 transposon that plays a role in DNA double-strand break repair, stalled replication fork restart and DNA integration. DNA-binding protein, it is indirectly recruited to sites of DNA damage through protein-protein interactions. Has also kept a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity (PubMed:16332963, PubMed:16672366, PubMed:17877369, PubMed:17403897, PubMed:18263876, PubMed:22231448, PubMed:24573677, PubMed:20521842). In parallel, has a histone methyltransferase activity and methylates 'Lys-4' and 'Lys-36' of histone H3. Specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining (PubMed:16332963, PubMed:21187428, PubMed:22231448). Also regulates replication fork processing, promoting replication fork restart and regulating DNA decatenation through stimulation of the topoisomerase activity of TOP2A (PubMed:18790802, PubMed:20457750). {ECO:0000269|PubMed:16332963, ECO:0000269|PubMed:16672366, ECO:0000269|PubMed:17403897, ECO:0000269|PubMed:17877369, ECO:0000269|PubMed:18790802, ECO:0000269|PubMed:20457750, ECO:0000269|PubMed:20521842, ECO:0000269|PubMed:21187428, ECO:0000269|PubMed:22231448, ECO:0000269|PubMed:24573677, ECO:0000303|PubMed:18263876}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Transposase 1|
|SET|
|Pre-SET|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone H3-K36 dimethylation|
|DNA topoisomerase binding|
|positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|regulation of DNA topoisomerase (ATP-hydrolyzing) activity|
|histone methyltransferase activity (H3-K36 specific)|
|histone H3-K36 methylation|
|regulation of isomerase activity|
|single-stranded DNA endodeoxyribonuclease activity|
|positive regulation of isomerase activity|
|positive regulation of double-strand break repair via nonhomologous end joining|
|peptidyl-lysine dimethylation|
|histone methyltransferase activity (H3-K4 specific)|
|DNA integration|
|DNA double-strand break processing|
|negative regulation of cell cycle arrest|
|DNA catabolic process, endonucleolytic|
|regulation of double-strand break repair via nonhomologous end joining|
|condensed chromosome|
|DNA catabolic process|
|replication fork processing|
|positive regulation of double-strand break repair|
|histone H3-K4 methylation|
|endonuclease activity|
|DNA-dependent DNA replication maintenance of fidelity|
|positive regulation of ATPase activity|
|site of double-strand break|
|double-strand break repair via nonhomologous end joining|
|non-recombinational repair|
|positive regulation of DNA repair|
|histone lysine methylation|
|regulation of double-strand break repair|
|regulation of ATPase activity|
|peptidyl-lysine methylation|
|histone methylation|
|positive regulation of response to DNA damage stimulus|
|double-stranded DNA binding|
|mitotic DNA integrity checkpoint|
|regulation of cell cycle arrest|
|single-stranded DNA binding|
|DNA-dependent DNA replication|
|regulation of DNA repair|
|protein alkylation|
|negative regulation of chromosome organization|
|protein methylation|
|DNA integrity checkpoint|
|mitotic cell cycle checkpoint|
|double-strand break repair|
|positive regulation of DNA metabolic process|
|cell cycle checkpoint|
|DNA replication|
|regulation of response to DNA damage stimulus|
|macromolecule methylation|
|nucleic acid phosphodiester bond hydrolysis|
|negative regulation of mitotic cell cycle|
|methylation|
|peptidyl-lysine modification|
|negative regulation of cell cycle process|
|regulation of chromosome organization|
|regulation of DNA metabolic process|
|histone modification|
|negative regulation of organelle organization|
|nucleobase-containing compound catabolic process|
|covalent chromatin modification|
|positive regulation of cell cycle|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|organic cyclic compound catabolic process|
|DNA repair|
|cell population proliferation|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cellular response to stress|
|DNA metabolic process|
|regulation of cell cycle process|
|positive regulation of hydrolase activity|
|cellular response to DNA damage stimulus|
|zinc ion binding|
|nucleolus|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|cell cycle process|
|macromolecule catabolic process|
|chromosome organization|
|regulation of cell cycle|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of catalytic activity|
|DNA binding|
|regulation of response to stress|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14327
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SETMAR Expression in NALM6 Cells: 4.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>