======= SF3A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SF3A2
  * **<color #00a2e8>Official Name</color>**: splicing factor 3a subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8175|8175]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15428|Q15428]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SF3A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SF3A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600796|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-met|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U2-type prespliceosome assembly|
|mRNA 3-splice site recognition|
|U2-type prespliceosome|
|U2 snRNP|
|mRNA splice site selection|
|U2-type precatalytic spliceosome|
|spliceosomal complex assembly|
|catalytic step 2 spliceosome|
|spliceosomal complex|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|positive regulation of neuron projection development|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|RNA splicing|
|nuclear speck|
|ribonucleoprotein complex biogenesis|
|positive regulation of neurogenesis|
|mRNA processing|
|regulation of neuron projection development|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|mRNA metabolic process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of neurogenesis|
|zinc ion binding|
|cellular protein-containing complex assembly|
|RNA processing|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|RNA binding|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|RNA metabolic process|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.74|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.76|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|1.78|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|1.8|
|[[:results:exp224|CB-839 10μM R05 exp224]]|1.82|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|1.82|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|1.84|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.86|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.96|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.98|
|[[:results:exp453|B02 10μM R08 exp453]]|1.99|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.02|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|2.14|
|[[:results:exp274|Citral 50μM R06 exp274]]|2.14|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.25|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:prim1|PRIM1]]|0.569|
|[[:human genes:p:polr2j3|POLR2J3]]|0.569|
|[[:human genes:t:tfip11|TFIP11]]|0.536|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.512|
|[[:human genes:e:eif3g|EIF3G]]|0.479|
|[[:human genes:s:sf3a3|SF3A3]]|0.467|
|[[:human genes:c:cep192|CEP192]]|0.461|
|[[:human genes:s:sf3a1|SF3A1]]|0.456|
|[[:human genes:s:snrpb|SNRPB]]|0.456|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.455|
|[[:human genes:s:syt9|SYT9]]|0.455|
|[[:human genes:t:tsg101|TSG101]]|0.454|
|[[:human genes:s:supt5h|SUPT5H]]|0.453|
|[[:human genes:r:rrp15|RRP15]]|0.453|
|[[:human genes:w:wbp11|WBP11]]|0.451|
|[[:human genes:c:c14orf93|C14orf93]]|0.446|
|[[:human genes:s:snrnp70|SNRNP70]]|0.446|
|[[:human genes:s:slc4a1|SLC4A1]]|0.445|
|[[:human genes:d:dtl|DTL]]|0.445|
|[[:human genes:o:osbp|OSBP]]|0.445|
|[[:human genes:c:cbwd6|CBWD6]]|0.443|
|[[:human genes:r:rpl35|RPL35]]|0.443|
|[[:human genes:r:rbm39|RBM39]]|0.438|
|[[:human genes:i:ints6|INTS6]]|0.437|
|[[:human genes:n:narfl|NARFL]]|0.433|
|[[:human genes:c:copg1|COPG1]]|0.433|
|[[:human genes:p:psmb4|PSMB4]]|0.432|
|[[:human genes:p:prpf19|PRPF19]]|0.431|
|[[:human genes:h:htatsf1|HTATSF1]]|0.431|
|[[:human genes:c:cdc5l|CDC5L]]|0.428|
|[[:human genes:c:cdc6|CDC6]]|0.425|
|[[:human genes:g:gar1|GAR1]]|0.42|
|[[:human genes:c:cdh24|CDH24]]|0.419|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.419|
|[[:human genes:c:cbwd3|CBWD3]]|0.418|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.418|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.417|
|[[:human genes:c:cactin|CACTIN]]|0.417|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.417|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.417|
|[[:human genes:m:mt1e|MT1E]]|0.415|
|[[:human genes:s:sf3b2|SF3B2]]|0.414|
|[[:human genes:g:golga6a|GOLGA6A]]|0.414|
|[[:human genes:s:sf3b5|SF3B5]]|0.413|
|[[:human genes:c:cbwd5|CBWD5]]|0.413|
|[[:human genes:p:plekha4|PLEKHA4]]|0.412|
|[[:human genes:c:cope|COPE]]|0.412|
|[[:human genes:d:dido1|DIDO1]]|0.411|
|[[:human genes:s:sf1|SF1]]|0.41|
|[[:human genes:s:snrpa1|SNRPA1]]|0.41|
|[[:human genes:c:ctage4|CTAGE4]]|0.41|
|[[:human genes:h:hinfp|HINFP]]|0.407|
|[[:human genes:a:aqr|AQR]]|0.406|
|[[:human genes:i:iscu|ISCU]]|0.405|
|[[:human genes:s:son|SON]]|0.404|
|[[:human genes:c:copz1|COPZ1]]|0.403|
|[[:human genes:c:ctr9|CTR9]]|0.403|
|[[:human genes:i:ik|IK]]|0.401|
|[[:human genes:s:strn|STRN]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 734/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|26/26|
|breast|33/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|19/20|
|lung|75/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 694
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SF3A2 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>