======= SFN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFN
  * **<color #00a2e8>Official Name</color>**: stratifin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2810|2810]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P31947|P31947]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|14-3-3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein kinase C inhibitor activity|
|regulation of epidermal cell division|
|keratinocyte development|
|negative regulation of keratinocyte proliferation|
|positive regulation of protein export from nucleus|
|release of cytochrome c from mitochondria|
|establishment of skin barrier|
|positive regulation of epidermal cell differentiation|
|regulation of water loss via skin|
|regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway|
|regulation of keratinocyte proliferation|
|positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|phosphoprotein binding|
|regulation of protein export from nucleus|
|positive regulation of epidermis development|
|regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|positive regulation of establishment of protein localization to mitochondrion|
|positive regulation of epithelial cell differentiation|
|apoptotic mitochondrial changes|
|regulation of epidermal cell differentiation|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|positive regulation of nucleocytoplasmic transport|
|G1 DNA damage checkpoint|
|multicellular organismal water homeostasis|
|intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of mitochondrial membrane permeability|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|regulation of establishment of protein localization to mitochondrion|
|signal transduction involved in cell cycle checkpoint|
|water homeostasis|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|regulation of membrane permeability|
|negative regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of epidermis development|
|negative regulation of cysteine-type endopeptidase activity|
|mitotic DNA damage checkpoint|
|regulation of cyclin-dependent protein serine/threonine kinase activity|
|negative regulation of G1/S transition of mitotic cell cycle|
|regulation of cyclin-dependent protein kinase activity|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|regulation of nucleocytoplasmic transport|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|positive regulation of mitochondrion organization|
|signal transduction by p53 class mediator|
|positive regulation of protein localization to membrane|
|negative regulation of epithelial cell proliferation|
|mitochondrial membrane organization|
|DNA damage checkpoint|
|negative regulation of protein serine/threonine kinase activity|
|regulation of epithelial cell differentiation|
|DNA integrity checkpoint|
|intrinsic apoptotic signaling pathway|
|regulation of G1/S transition of mitotic cell cycle|
|mitotic cell cycle checkpoint|
|positive regulation of intracellular protein transport|
|positive regulation of cell growth|
|regulation of cell cycle G1/S phase transition|
|regulation of cell division|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|regulation of protein localization to membrane|
|epithelial cell development|
|cell cycle checkpoint|
|positive regulation of intracellular transport|
|negative regulation of mitotic cell cycle phase transition|
|mitochondrial transport|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of protein kinase activity|
|keratinization|
|regulation of intracellular protein transport|
|negative regulation of cell cycle phase transition|
|regulation of cysteine-type endopeptidase activity|
|negative regulation of endopeptidase activity|
|protein domain specific binding|
|negative regulation of kinase activity|
|negative regulation of peptidase activity|
|positive regulation of growth|
|keratinocyte differentiation|
|negative regulation of transferase activity|
|apoptotic signaling pathway|
|positive regulation of cell cycle process|
|negative regulation of mitotic cell cycle|
|cadherin binding|
|epidermal cell differentiation|
|multicellular organismal homeostasis|
|positive regulation of cellular protein localization|
|negative regulation of cell cycle process|
|regulation of epithelial cell proliferation|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|positive regulation of cell cycle|
|skin development|
|regulation of apoptotic signaling pathway|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|epidermis development|
|regulation of endopeptidase activity|
|regulation of cell growth|
|positive regulation of protein transport|
|mitochondrion organization|
|regulation of peptidase activity|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|negative regulation of hydrolase activity|
|positive regulation of establishment of protein localization|
|protein kinase binding|
|regulation of body fluid levels|
|regulation of protein serine/threonine kinase activity|
|regulation of cellular protein localization|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|negative regulation of protein modification process|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|regulation of growth|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|mitotic cell cycle|
|positive regulation of cell death|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|membrane organization|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|apoptotic process|
|positive regulation of cell differentiation|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cell death|
|cell cycle process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|mitochondrion|
|regulation of hydrolase activity|
|regulation of organelle organization|
|cell cycle|
|positive regulation of developmental process|
|regulation of protein phosphorylation|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|regulation of cell population proliferation|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8732
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFN Expression in NALM6 Cells: 2.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>