======= SFSWAP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFSWAP
  * **<color #00a2e8>Official Name</color>**: splicing factor SWAP
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6433|6433]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q12872|Q12872]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFSWAP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFSWAP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role as an alternative splicing regulator. Regulate its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:8940107}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Surp|
|DRY EERY|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mRNA 5-splice site recognition|
|alternative mRNA splicing, via spliceosome|
|negative regulation of mRNA splicing, via spliceosome|
|negative regulation of RNA splicing|
|negative regulation of mRNA processing|
|mRNA splice site selection|
|mRNA cis splicing, via spliceosome|
|spliceosomal complex assembly|
|negative regulation of mRNA metabolic process|
|regulation of mRNA splicing, via spliceosome|
|regulation of RNA splicing|
|regulation of mRNA processing|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|regulation of mRNA metabolic process|
|RNA splicing|
|ribonucleoprotein complex biogenesis|
|mRNA processing|
|mRNA metabolic process|
|cellular protein-containing complex assembly|
|RNA processing|
|negative regulation of RNA metabolic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|protein-containing complex assembly|
|RNA metabolic process|
|negative regulation of gene expression|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.75|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.78|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.8|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 78/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|5/28|
|bone|5/26|
|breast|4/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|3/21|
|liver|1/20|
|lung|8/75|
|lymphocyte|3/16|
|ovary|3/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|1/2|
|upper aerodigestive|4/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1290
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.57 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFSWAP Expression in NALM6 Cells: 6.57'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>