======= SFXN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SFXN4
  * **<color #00a2e8>Official Name</color>**: sideroflexin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=119559|119559]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6P4A7|Q6P4A7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SFXN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SFXN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615564|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sideroflexin family. The encoded protein is a transmembrane protein of the inner mitochondrial membrane, and is required for mitochondrial respiratory homeostasis and erythropoiesis. Mutations in this gene are associated with mitochondriopathy and macrocytic anemia. Alternatively spliced transcript variants have been found in this gene. [provided by RefSeq, Jan 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Potential iron transporter. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mtc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ion transmembrane transporter activity|
|amino acid transport|
|organic acid transport|
|carboxylic acid transport|
|mitochondrial inner membrane|
|organic anion transport|
|anion transport|
|intracellular membrane-bounded organelle|
|ion transmembrane transport|
|mitochondrion|
|transmembrane transport|
|ion transport|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.7|
|[[:results:exp534|Trientine 500μM R08 exp534]]|1.72|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.76|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.77|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|1.79|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.81|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.81|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|1.81|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.06|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.17|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.31|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|2.33|
|[[:results:exp52|Ribavirin 10μM R01 exp52]]|2.74|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.89|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|3.69|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mcat|MCAT]]|0.558|
|[[:human genes:a:acad9|ACAD9]]|0.53|
|[[:human genes:g:grsf1|GRSF1]]|0.528|
|[[:human genes:f:fastkd2|FASTKD2]]|0.517|
|[[:human genes:m:mto1|MTO1]]|0.513|
|[[:human genes:n:nubpl|NUBPL]]|0.503|
|[[:human genes:m:mtif2|MTIF2]]|0.502|
|[[:human genes:n:ndufb10|NDUFB10]]|0.5|
|[[:human genes:m:mpv17l2|MPV17L2]]|0.493|
|[[:human genes:s:ssbp1|SSBP1]]|0.493|
|[[:human genes:p:pde12|PDE12]]|0.481|
|[[:human genes:t:tsfm|TSFM]]|0.473|
|[[:human genes:f:foxred1|FOXRED1]]|0.469|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.468|
|[[:human genes:n:ndufb9|NDUFB9]]|0.461|
|[[:human genes:n:noa1|NOA1]]|0.459|
|[[:human genes:m:mtg1|MTG1]]|0.457|
|[[:human genes:n:nsun4|NSUN4]]|0.454|
|[[:human genes:c:coq7|COQ7]]|0.452|
|[[:human genes:n:ndufs2|NDUFS2]]|0.445|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.436|
|[[:human genes:n:ndufaf6|NDUFAF6]]|0.435|
|[[:human genes:c:chchd1|CHCHD1]]|0.435|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.435|
|[[:human genes:i:iba57|IBA57]]|0.434|
|[[:human genes:i:ict1|ICT1]]|0.428|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.428|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.428|
|[[:human genes:n:ndufa3|NDUFA3]]|0.427|
|[[:human genes:n:ndufc1|NDUFC1]]|0.426|
|[[:human genes:p:pet112|PET112]]|0.425|
|[[:human genes:n:ndufb7|NDUFB7]]|0.424|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.422|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.419|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.417|
|[[:human genes:r:rpusd3|RPUSD3]]|0.415|
|[[:human genes:n:ndufa1|NDUFA1]]|0.415|
|[[:human genes:p:prepl|PREPL]]|0.414|
|[[:human genes:n:ndufa11|NDUFA11]]|0.412|
|[[:human genes:r:rexo2|REXO2]]|0.411|
|[[:human genes:r:rmnd1|RMND1]]|0.408|
|[[:human genes:d:ddx28|DDX28]]|0.408|
|[[:human genes:n:ndufb11|NDUFB11]]|0.405|
|[[:human genes:e:eral1|ERAL1]]|0.405|
|[[:human genes:n:ndufa10|NDUFA10]]|0.403|
|[[:human genes:e:ecsit|ECSIT]]|0.402|
|[[:human genes:p:pdss2|PDSS2]]|0.401|
|[[:human genes:n:ndufaf1|NDUFAF1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1711
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SFXN4 Expression in NALM6 Cells: 5.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>