======= SGMS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SGMS1
  * **<color #00a2e8>Official Name</color>**: sphingomyelin synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=259230|259230]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86VZ5|Q86VZ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SGMS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SGMS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611573|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAP2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ceramide phosphoethanolamine synthase activity|
|ceramide cholinephosphotransferase activity|
|sphingomyelin synthase activity|
|sphingomyelin biosynthetic process|
|Golgi trans cisterna|
|sphingomyelin metabolic process|
|ceramide biosynthetic process|
|integral component of Golgi membrane|
|kinase activity|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|integral component of endoplasmic reticulum membrane|
|membrane lipid biosynthetic process|
|sphingolipid metabolic process|
|regulation of intrinsic apoptotic signaling pathway|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|ammonium ion metabolic process|
|membrane lipid metabolic process|
|cellular response to biotic stimulus|
|cellular response to tumor necrosis factor|
|phospholipid biosynthetic process|
|response to tumor necrosis factor|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|phospholipid metabolic process|
|regulation of apoptotic signaling pathway|
|inflammatory response|
|cellular response to lipid|
|amide biosynthetic process|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|Golgi membrane|
|response to bacterium|
|cellular amide metabolic process|
|response to lipid|
|organophosphate metabolic process|
|apoptotic process|
|cellular lipid metabolic process|
|cellular response to cytokine stimulus|
|endoplasmic reticulum|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell death|
|response to cytokine|
|lipid metabolic process|
|phosphorylation|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular nitrogen compound biosynthetic process|
|regulation of cell death|
|regulation of intracellular signal transduction|
|positive regulation of gene expression|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-4.01|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-3.43|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-3.38|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.34|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.98|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.28|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.26|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.25|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.03|
|[[:results:exp461|BS-181 20μM R08 exp461]]|-1.96|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.88|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.78|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.76|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:col4a3bp|COL4A3BP]]|0.597|
|[[:human genes:c:cog5|COG5]]|0.482|
|[[:human genes:s:sptlc1|SPTLC1]]|0.481|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.469|
|[[:human genes:u:unc50|UNC50]]|0.455|
|[[:human genes:t:tbc1d23|TBC1D23]]|0.429|
|[[:human genes:d:dym|DYM]]|0.416|
|[[:human genes:c:cog7|COG7]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7270
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SGMS1 Expression in NALM6 Cells: 3.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>