======= SH3GL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3GL1
  * **<color #00a2e8>Official Name</color>**: SH3 domain containing GRB2 like 1, endophilin A2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6455|6455]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99961|Q99961]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3GL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3GL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601768|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|SH3 1|
|BAR 2|
|BAR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|beta-1 adrenergic receptor binding|
|synaptic vesicle uncoating|
|clathrin coat disassembly|
|positive regulation of synaptic vesicle endocytosis|
|vesicle uncoating|
|positive regulation of synaptic vesicle recycling|
|regulation of synaptic vesicle endocytosis|
|postsynaptic density, intracellular component|
|regulation of synaptic vesicle recycling|
|podosome|
|GTPase binding|
|hippocampal mossy fiber to CA3 synapse|
|protein depolymerization|
|modulation of excitatory postsynaptic potential|
|synaptic vesicle endocytosis|
|presynaptic endocytosis|
|phosphatase binding|
|synaptic vesicle recycling|
|Schaffer collateral - CA1 synapse|
|presynapse|
|cell projection|
|positive regulation of endocytosis|
|regulation of synaptic vesicle cycle|
|synaptic vesicle cycle|
|ion channel binding|
|vesicle-mediated transport in synapse|
|SH3 domain binding|
|regulation of nervous system process|
|cellular protein complex disassembly|
|early endosome membrane|
|lipid binding|
|protein C-terminus binding|
|regulation of endocytosis|
|protein-containing complex disassembly|
|cadherin binding|
|glutamatergic synapse|
|cellular component disassembly|
|regulation of membrane potential|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cell junction|
|regulation of vesicle-mediated transport|
|endocytosis|
|regulation of system process|
|import into cell|
|regulation of cellular localization|
|central nervous system development|
|positive regulation of transport|
|identical protein binding|
|positive regulation of cellular component organization|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.9|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-2.78|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.66|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.57|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.54|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.46|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.3|
|[[:results:exp169|BH1 1μM R04 exp169]]|-2.27|
|[[:results:exp210|LB-100 2μM R05 exp210]]|-2.03|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.94|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.94|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.89|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.89|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.89|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.88|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.73|
|[[:results:exp270|Campthothecin 0.001μM R06 exp270]]|-1.7|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|1.71|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|1.84|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|1.93|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.05|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.13|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.49|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:itsn2|ITSN2]]|0.52|
|[[:human genes:a:agfg1|AGFG1]]|0.447|
|[[:human genes:r:rab5c|RAB5C]]|0.442|
|[[:human genes:a:ap2s1|AP2S1]]|0.416|
|[[:human genes:g:gdi2|GDI2]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|5/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8638
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3GL1 Expression in NALM6 Cells: 4.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>