======= SH3GLB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SH3GLB1
  * **<color #00a2e8>Official Name</color>**: SH3 domain containing GRB2 like, endophilin B1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51100|51100]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y371|Q9Y371]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SH3GLB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SH3GLB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609287|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for normal outer mitochondrial membrane dynamics (PubMed:15452144). Required for coatomer-mediated retrograde transport in certain cells (By similarity). May recruit other proteins to membranes with high curvature. May promote membrane fusion (PubMed:11604418). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (By similarity). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2) (PubMed:17891140). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation (PubMed:21068542). Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (By similarity). {ECO:0000250|UniProtKB:Q9JK48, ECO:0000269|PubMed:11604418, ECO:0000269|PubMed:15452144, ECO:0000269|PubMed:17891140, ECO:0000269|PubMed:20643123, ECO:0000269|PubMed:21068542}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|BAR|
|SH3 1|
|BAR 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein localization to vacuolar membrane|
|positive regulation of membrane tubulation|
|regulation of membrane tubulation|
|autophagic cell death|
|positive regulation of autophagosome assembly|
|membrane fission|
|positive regulation of vacuole organization|
|regulation of plasma membrane organization|
|positive regulation of protein oligomerization|
|receptor catabolic process|
|positive regulation of protein targeting to mitochondrion|
|autophagosome membrane|
|regulation of autophagosome assembly|
|cellular response to glucose starvation|
|regulation of vacuole organization|
|regulation of protein oligomerization|
|cellular response to amino acid starvation|
|regulation of protein targeting to mitochondrion|
|response to amino acid starvation|
|positive regulation of establishment of protein localization to mitochondrion|
|protein localization to vacuole|
|positive regulation of macroautophagy|
|regulation of establishment of protein localization to mitochondrion|
|positive regulation of organelle assembly|
|regulation of protein targeting|
|regulation of cytokinesis|
|receptor metabolic process|
|positive regulation of mitochondrion organization|
|positive regulation of autophagy|
|cellular response to starvation|
|positive regulation of intracellular protein transport|
|lipid binding|
|midbody|
|mitochondrial outer membrane|
|regulation of cell division|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|response to starvation|
|positive regulation of intracellular transport|
|regulation of organelle assembly|
|regulation of intracellular protein transport|
|cellular response to nutrient levels|
|positive regulation of protein complex assembly|
|cytoplasmic vesicle|
|process utilizing autophagic mechanism|
|autophagy|
|cellular response to extracellular stimulus|
|regulation of protein stability|
|cadherin binding|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|cellular response to external stimulus|
|regulation of intracellular transport|
|positive regulation of cellular catabolic process|
|positive regulation of protein transport|
|positive regulation of catabolic process|
|regulation of protein complex assembly|
|positive regulation of establishment of protein localization|
|protein localization to membrane|
|response to nutrient levels|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|response to extracellular stimulus|
|regulation of cellular protein localization|
|Golgi membrane|
|positive regulation of organelle organization|
|regulation of protein transport|
|protein localization to organelle|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cell cycle process|
|regulation of cellular catabolic process|
|membrane organization|
|protein homodimerization activity|
|regulation of cellular localization|
|apoptotic process|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|programmed cell death|
|identical protein binding|
|cell death|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|protein-containing complex assembly|
|cellular protein localization|
|cellular macromolecule localization|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp471|Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471]]|-1.77|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-1.77|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.73|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|1.71|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.79|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14076
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SH3GLB1 Expression in NALM6 Cells: 5.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>