======= SHANK2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHANK2
  * **<color #00a2e8>Official Name</color>**: SH3 and multiple ankyrin repeat domains 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22941|22941]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPX8|Q9UPX8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHANK2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHANK2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ank 2|
|SAM 2|
|PDZ|
|SAM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GKAP/Homer scaffold activity|
|synaptic growth at neuromuscular junction|
|neuron spine|
|postsynaptic density assembly|
|neurofilament|
|postsynaptic specialization assembly|
|ionotropic glutamate receptor complex|
|excitatory synapse assembly|
|postsynaptic density organization|
|long-term synaptic depression|
|dendritic spine morphogenesis|
|postsynaptic specialization organization|
|vocalization behavior|
|postsynapse assembly|
|receptor signaling complex adaptor activity|
|regulation of AMPA receptor activity|
|positive regulation of excitatory postsynaptic potential|
|dendritic spine development|
|dendritic spine organization|
|positive regulation of synaptic transmission, glutamatergic|
|ionotropic glutamate receptor binding|
|brain morphogenesis|
|neuron projection organization|
|modulation of excitatory postsynaptic potential|
|neuromuscular junction development|
|positive regulation of dendritic spine development|
|long-term synaptic potentiation|
|photoreceptor inner segment|
|social behavior|
|intraspecies interaction between organisms|
|brush border membrane|
|ciliary membrane|
|dendrite morphogenesis|
|photoreceptor outer segment|
|negative regulation of synaptic transmission|
|positive regulation of nervous system process|
|regulation of glutamate receptor signaling pathway|
|multi-organism behavior|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of dendrite development|
|regulation of dendritic spine development|
|regulation of neurotransmitter receptor activity|
|postsynapse organization|
|synapse assembly|
|dendrite development|
|growth cone|
|SH3 domain binding|
|regulation of nervous system process|
|adult behavior|
|learning|
|dendritic spine|
|regulation of dendrite development|
|positive regulation of synaptic transmission|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|postsynaptic density|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|synapse organization|
|regulation of transporter activity|
|positive regulation of neuron projection development|
|cognition|
|apical plasma membrane|
|neuron projection|
|regulation of cation transmembrane transport|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell projection organization|
|developmental growth|
|growth|
|dendrite|
|regulation of membrane potential|
|cell morphogenesis involved in neuron differentiation|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|cellular component|
|positive regulation of neurogenesis|
|regulation of ion transmembrane transport|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell part morphogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|cell morphogenesis involved in differentiation|
|regulation of transmembrane transport|
|behavior|
|regulation of system process|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|regulation of ion transport|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|organelle assembly|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: N/A
^Tissue^Fraction Of Cell Lines Where Essential^
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12125
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHANK2 Expression in NALM6 Cells: 0.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>