======= SHMT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SHMT1
  * **<color #00a2e8>Official Name</color>**: serine hydroxymethyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6470|6470]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P34896|P34896]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SHMT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SHMT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160). {ECO:0000269|PubMed:24698160, ECO:0000269|PubMed:8505317}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SHMT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-allo-threonine aldolase activity|
|glycine biosynthetic process from serine|
|response to tetrahydrofolate|
|glycine hydroxymethyltransferase activity|
|cellular response to tetrahydrofolate|
|cobalt ion binding|
|serine binding|
|dTMP metabolic process|
|glycine biosynthetic process|
|dTMP biosynthetic process|
|L-serine catabolic process|
|carnitine biosynthetic process|
|pyrimidine deoxyribonucleoside monophosphate biosynthetic process|
|pyrimidine deoxyribonucleoside monophosphate metabolic process|
|amino-acid betaine biosynthetic process|
|pyrimidine deoxyribonucleotide biosynthetic process|
|deoxyribonucleoside monophosphate biosynthetic process|
|tetrahydrofolate interconversion|
|purine nucleobase biosynthetic process|
|deoxyribose phosphate biosynthetic process|
|L-serine metabolic process|
|2-deoxyribonucleotide biosynthetic process|
|deoxyribonucleoside monophosphate metabolic process|
|carnitine metabolic process|
|serine family amino acid catabolic process|
|deoxyribonucleotide biosynthetic process|
|translation repressor activity, mRNA regulatory element binding|
|pyrimidine nucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside monophosphate metabolic process|
|serine family amino acid biosynthetic process|
|amino acid binding|
|amino-acid betaine metabolic process|
|glycine metabolic process|
|tetrahydrofolate metabolic process|
|nucleobase biosynthetic process|
|folic acid metabolic process|
|pyrimidine deoxyribonucleotide metabolic process|
|purine nucleobase metabolic process|
|mRNA 5-UTR binding|
|one-carbon metabolic process|
|folic acid-containing compound metabolic process|
|2-deoxyribonucleotide metabolic process|
|deoxyribose phosphate metabolic process|
|pteridine-containing compound metabolic process|
|deoxyribonucleotide metabolic process|
|serine family amino acid metabolic process|
|nucleobase metabolic process|
|neurotransmitter biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|cellular modified amino acid biosynthetic process|
|pyrimidine nucleotide biosynthetic process|
|pigment biosynthetic process|
|pyridoxal phosphate binding|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|pigment metabolic process|
|alpha-amino acid biosynthetic process|
|nucleoside monophosphate metabolic process|
|cellular amino acid biosynthetic process|
|water-soluble vitamin metabolic process|
|neurotransmitter metabolic process|
|protein homotetramerization|
|cellular response to leukemia inhibitory factor|
|response to leukemia inhibitory factor|
|dicarboxylic acid metabolic process|
|pyrimidine-containing compound metabolic process|
|alpha-amino acid catabolic process|
|vitamin metabolic process|
|cellular amino acid catabolic process|
|negative regulation of translation|
|negative regulation of cellular amide metabolic process|
|protein tetramerization|
|purine-containing compound biosynthetic process|
|ammonium ion metabolic process|
|cellular modified amino acid metabolic process|
|cellular response to acid chemical|
|alpha-amino acid metabolic process|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|coenzyme metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|cellular amino acid metabolic process|
|protein homooligomerization|
|response to acid chemical|
|regulation of translation|
|regulation of neurotransmitter levels|
|purine-containing compound metabolic process|
|regulation of cellular amide metabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|drug metabolic process|
|protein complex oligomerization|
|posttranscriptional regulation of gene expression|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|cellular response to organic cyclic compound|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|carbohydrate derivative biosynthetic process|
|cellular response to nitrogen compound|
|cellular amide metabolic process|
|zinc ion binding|
|protein homodimerization activity|
|organophosphate metabolic process|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|response to organonitrogen compound|
|oxoacid metabolic process|
|cellular response to cytokine stimulus|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|negative regulation of protein metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|cellular response to endogenous stimulus|
|organic cyclic compound biosynthetic process|
|negative regulation of cellular macromolecule biosynthetic process|
|organonitrogen compound biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|negative regulation of gene expression|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.89|
|[[:results:exp220|BAY-598 4μM R05 exp220]]|-1.82|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SHMT1 Expression in NALM6 Cells: 5.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>