======= SIGMAR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIGMAR1
  * **<color #00a2e8>Official Name</color>**: sigma non-opioid intracellular receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10280|10280]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99720|Q99720]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIGMAR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIGMAR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601978|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a receptor protein that interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. The receptor is believed to play an important role in the cellular functions of various tissues associated with the endocrine, immune, and nervous systems. As indicated by its previous name, opioid receptor sigma 1 (OPRS1), the product of this gene was erroneously thought to function as an opioid receptor; it is now thought to be a non-opioid receptor. Mutations in this gene has been associated with juvenile amyotrophic lateral sclerosis 16. Alternative splicing of this gene results in transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ERG2 Sigma1R|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell death in response to hydrogen peroxide|
|opioid receptor activity|
|opioid receptor signaling pathway|
|cell death in response to oxidative stress|
|nuclear outer membrane|
|protein homotrimerization|
|nuclear inner membrane|
|protein trimerization|
|drug binding|
|cellular response to hydrogen peroxide|
|lipid droplet|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|growth cone|
|cellular response to reactive oxygen species|
|nuclear envelope|
|response to reactive oxygen species|
|postsynaptic membrane|
|regulation of neuron apoptotic process|
|cellular response to toxic substance|
|cellular response to oxidative stress|
|postsynaptic density|
|cytoplasmic vesicle|
|lipid transport|
|response to antibiotic|
|regulation of neuron death|
|lipid localization|
|protein homooligomerization|
|response to oxidative stress|
|cellular response to drug|
|response to toxic substance|
|protein complex oligomerization|
|response to inorganic substance|
|cell junction|
|endoplasmic reticulum membrane|
|endoplasmic reticulum|
|response to drug|
|cellular response to oxygen-containing compound|
|cell death|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of programmed cell death|
|regulation of cell death|
|cellular response to stress|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10602
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIGMAR1 Expression in NALM6 Cells: 3.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>