======= SIN3A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIN3A
  * **<color #00a2e8>Official Name</color>**: SIN3 transcription regulator family member A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25942|25942]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96ST3|Q96ST3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIN3A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIN3A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607776|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in he control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (By similarity). {ECO:0000250|UniProtKB:Q60520, ECO:0000269|PubMed:12150998}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PAH|
|HDAC interact|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of histone H3-K27 acetylation|
|regulation of histone H3-K27 acetylation|
|response to methylglyoxal|
|protein deacetylase activity|
|regulation of transcription from RNA polymerase II promoter in response to oxidative stress|
|Sin3 complex|
|positive regulation of chromatin silencing|
|negative regulation of histone acetylation|
|negative regulation of circadian rhythm|
|negative regulation of peptidyl-lysine acetylation|
|negative regulation of transcription regulatory region DNA binding|
|negative regulation of protein acetylation|
|cerebral cortex neuron differentiation|
|positive regulation of defense response to virus by host|
|positive regulation of G2/M transition of mitotic cell cycle|
|histone deacetylase activity|
|negative regulation of protein localization to nucleus|
|positive regulation of cell cycle G2/M phase transition|
|RNA polymerase II repressing transcription factor binding|
|regulation of defense response to virus by host|
|regulation of chromatin silencing|
|negative regulation of histone modification|
|histone deacetylation|
|protein deacetylation|
|regulation of transcription regulatory region DNA binding|
|RNA polymerase II activating transcription factor binding|
|regulation of megakaryocyte differentiation|
|negative regulation of DNA binding|
|regulation of histone acetylation|
|transcriptional repressor complex|
|negative regulation of chromatin organization|
|protein deacylation|
|macromolecule deacylation|
|regulation of peptidyl-lysine acetylation|
|cellular response to glucose stimulus|
|cellular response to hexose stimulus|
|regulation of protein acetylation|
|cellular response to monosaccharide stimulus|
|regulation of defense response to virus|
|transcription regulatory region sequence-specific DNA binding|
|positive regulation of mitotic cell cycle phase transition|
|cellular response to carbohydrate stimulus|
|cellular response to dopamine|
|kinetochore|
|response to dopamine|
|hematopoietic progenitor cell differentiation|
|cellular glucose homeostasis|
|positive regulation of cell cycle phase transition|
|regulation of axon extension|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|positive regulation of chromatin organization|
|response to catecholamine|
|response to monoamine|
|regulation of extent of cell growth|
|negative regulation of cellular protein localization|
|chromatin|
|regulation of circadian rhythm|
|regulation of protein localization to nucleus|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|regulation of DNA binding|
|regulation of gene silencing|
|cellular response to ammonium ion|
|negative regulation of chromosome organization|
|response to glucose|
|response to hexose|
|regulation of histone modification|
|response to monosaccharide|
|positive regulation of mitotic cell cycle|
|negative regulation of binding|
|response to carbohydrate|
|positive regulation of chromosome organization|
|central nervous system neuron differentiation|
|regulation of cell size|
|glucose homeostasis|
|response to ammonium ion|
|regulation of axonogenesis|
|carbohydrate homeostasis|
|regulation of chromatin organization|
|response to ketone|
|regulation of G2/M transition of mitotic cell cycle|
|transcription factor complex|
|regulation of cell cycle G2/M phase transition|
|DNA replication|
|regulation of myeloid cell differentiation|
|cellular response to oxidative stress|
|transcription corepressor activity|
|activation of innate immune response|
|protein-containing complex binding|
|rhythmic process|
|aging|
|positive regulation of cell cycle process|
|regulation of cell morphogenesis involved in differentiation|
|regulation of developmental growth|
|positive regulation of innate immune response|
|regulation of chromosome organization|
|positive regulation of response to biotic stimulus|
|histone modification|
|positive regulation of neuron differentiation|
|negative regulation of organelle organization|
|covalent chromatin modification|
|regulation of cellular component size|
|in utero embryonic development|
|regulation of binding|
|positive regulation of cell cycle|
|forebrain development|
|response to oxidative stress|
|chromatin binding|
|regulation of lipid metabolic process|
|cellular response to drug|
|regulation of mitotic cell cycle phase transition|
|regulation of cell growth|
|regulation of cell cycle phase transition|
|regulation of hemopoiesis|
|regulation of innate immune response|
|regulation of immune effector process|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|positive regulation of multi-organism process|
|regulation of anatomical structure size|
|regulation of response to biotic stimulus|
|regulation of hormone levels|
|positive regulation of nervous system development|
|regulation of cellular protein localization|
|positive regulation of cell development|
|cellular response to organic cyclic compound|
|hemopoiesis|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|positive regulation of response to external stimulus|
|hematopoietic or lymphoid organ development|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|activation of immune response|
|chordate embryonic development|
|immune system development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|regulation of plasma membrane bounded cell projection organization|
|chromatin organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|brain development|
|cellular chemical homeostasis|
|regulation of cell cycle process|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|regulation of neurogenesis|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cellular localization|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|embryo development|
|central nervous system development|
|negative regulation of cell death|
|response to organonitrogen compound|
|neuron differentiation|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|chromosome organization|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|negative regulation of molecular function|
|regulation of immune response|
|positive regulation of immune system process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.85|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.63|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.41|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.3|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.23|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.23|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|-2.12|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|-2.09|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-2.02|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.97|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-1.96|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|-1.88|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.81|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.81|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.81|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.8|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-1.79|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.78|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.77|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.76|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.75|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.75|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.74|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.7|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.86|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.26|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|2.47|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.53|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.66|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|2.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:ing1|ING1]]|0.623|
|[[:human genes:s:sap130|SAP130]]|0.571|
|[[:human genes:b:brms1|BRMS1]]|0.508|
|[[:human genes:s:suds3|SUDS3]]|0.492|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 111/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|3/25|
|breast|12/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|2/21|
|liver|5/20|
|lung|7/75|
|lymphocyte|3/14|
|ovary|8/26|
|pancreas|3/24|
|peripheral nervous system|5/16|
|plasma cell|5/15|
|prostate|1/1|
|skin|3/24|
|soft tissue|2/7|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2363
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.1 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIN3A Expression in NALM6 Cells: 7.1'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>