======= SIRT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIRT2
  * **<color #00a2e8>Official Name</color>**: sirtuin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22933|22933]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IXJ6|Q8IXJ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIRT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIRT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604480|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SIR2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|NAD-dependent histone deacetylase activity (H4-K16 specific)|
|cellular response to caloric restriction|
|negative regulation of oligodendrocyte progenitor proliferation|
|positive regulation of oocyte maturation|
|tubulin deacetylation|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia|
|tubulin deacetylase activity|
|response to caloric restriction|
|lateral loop|
|NAD-dependent histone deacetylase activity|
|positive regulation of oocyte development|
|negative regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|positive regulation of oogenesis|
|NAD-dependent protein deacetylase activity|
|positive regulation of attachment of spindle microtubules to kinetochore|
|chromatin silencing at telomere|
|negative regulation of defense response to bacterium|
|regulation of oocyte maturation|
|negative regulation of NLRP3 inflammasome complex assembly|
|chromatin silencing complex|
|paranodal junction|
|regulation of oligodendrocyte progenitor proliferation|
|peptidyl-lysine deacetylation|
|positive regulation of cell maturation|
|juxtaparanode region of axon|
|meiotic spindle|
|glial cell projection|
|regulation of oocyte development|
|regulation of oogenesis|
|protein deacetylase activity|
|Schmidt-Lanterman incisure|
|histone H4 deacetylation|
|negative regulation of transcription from RNA polymerase II promoter in response to stress|
|chromatin silencing at rDNA|
|paranode region of axon|
|hepatocyte growth factor receptor signaling pathway|
|regulation of attachment of spindle microtubules to kinetochore|
|cellular response to epinephrine stimulus|
|positive regulation of meiotic nuclear division|
|response to redox state|
|positive regulation of execution phase of apoptosis|
|regulation of NLRP3 inflammasome complex assembly|
|NAD+ binding|
|cellular response to hepatocyte growth factor stimulus|
|response to epinephrine|
|regulation of defense response to bacterium|
|response to hepatocyte growth factor|
|negative regulation of peptidyl-threonine phosphorylation|
|regulation of exit from mitosis|
|histone H3 deacetylation|
|nuclear heterochromatin|
|regulation of cell maturation|
|negative regulation of neural precursor cell proliferation|
|positive regulation of meiotic cell cycle|
|peripheral nervous system axon ensheathment|
|myelination in peripheral nervous system|
|histone deacetylase activity|
|NAD+ ADP-ribosyltransferase activity|
|positive regulation of chromosome segregation|
|Schwann cell development|
|histone acetyltransferase binding|
|protein ADP-ribosylation|
|regulation of meiotic nuclear division|
|myelin sheath|
|phosphatidylinositol 3-kinase signaling|
|Schwann cell differentiation|
|protein kinase B signaling|
|regulation of execution phase of apoptosis|
|negative regulation of gliogenesis|
|regulation of myelination|
|substantia nigra development|
|regulation of peptidyl-threonine phosphorylation|
|negative regulation of fat cell differentiation|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of meiotic cell cycle|
|histone deacetylation|
|chromosome, telomeric region|
|negative regulation of muscle tissue development|
|protein deacetylation|
|negative regulation of reactive oxygen species metabolic process|
|positive regulation of DNA binding|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|protein deacylation|
|neural nucleus development|
|macromolecule deacylation|
|positive regulation of nuclear division|
|chromatin organization involved in regulation of transcription|
|phosphatidylinositol-mediated signaling|
|peripheral nervous system development|
|inositol lipid-mediated signaling|
|mitotic spindle|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|positive regulation of reproductive process|
|ubiquitin binding|
|negative regulation of gene expression, epigenetic|
|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|
|negative regulation of autophagy|
|midbrain development|
|positive regulation of cell division|
|regulation of neural precursor cell proliferation|
|negative regulation of response to biotic stimulus|
|positive regulation of ubiquitin-dependent protein catabolic process|
|cellular response to catecholamine stimulus|
|cellular response to monoamine stimulus|
|regulation of chromosome segregation|
|positive regulation of proteasomal protein catabolic process|
|response to catecholamine|
|myelination|
|response to monoamine|
|glial cell development|
|axon ensheathment|
|ensheathment of neurons|
|histone deacetylase binding|
|regulation of gliogenesis|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|spindle|
|positive regulation of proteolysis involved in cellular protein catabolic process|
|regulation of fat cell differentiation|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|chromosome|
|regulation of DNA-templated transcription in response to stress|
|regulation of DNA binding|
|growth cone|
|negative regulation of protein complex assembly|
|regulation of striated muscle tissue development|
|negative regulation of protein catabolic process|
|perikaryon|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|positive regulation of cellular protein catabolic process|
|centriole|
|gene silencing|
|regulation of ubiquitin-dependent protein catabolic process|
|midbody|
|regulation of reproductive process|
|regulation of cell division|
|regulation of mitotic nuclear division|
|glial cell differentiation|
|positive regulation of binding|
|regulation of reactive oxygen species metabolic process|
|regulation of proteasomal protein catabolic process|
|cellular response to hypoxia|
|cellular response to molecule of bacterial origin|
|regulation of nuclear division|
|cellular lipid catabolic process|
|cellular response to decreased oxygen levels|
|negative regulation of defense response|
|gliogenesis|
|cellular response to oxygen levels|
|cellular response to biotic stimulus|
|negative regulation of multi-organism process|
|regulation of proteolysis involved in cellular protein catabolic process|
|positive regulation of protein catabolic process|
|meiotic cell cycle|
|regulation of gene expression, epigenetic|
|cellular response to oxidative stress|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|autophagy|
|process utilizing autophagic mechanism|
|positive regulation of cell cycle process|
|negative regulation of neurogenesis|
|lipid catabolic process|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|peptidyl-lysine modification|
|microtubule|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to molecule of bacterial origin|
|regulation of autophagy|
|transcription factor binding|
|negative regulation of cell development|
|response to hypoxia|
|proteasomal protein catabolic process|
|positive regulation of proteolysis|
|response to decreased oxygen levels|
|histone modification|
|negative regulation of response to external stimulus|
|positive regulation of cellular catabolic process|
|covalent chromatin modification|
|regulation of binding|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of protein catabolic process|
|response to oxidative stress|
|chromatin binding|
|negative regulation of protein phosphorylation|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|negative regulation of phosphorylation|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|centrosome|
|cell division|
|response to nutrient levels|
|cellular response to growth factor stimulus|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|response to growth factor|
|modification-dependent protein catabolic process|
|cellular response to organic cyclic compound|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular response to organonitrogen compound|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|cellular response to nitrogen compound|
|negative regulation of cell population proliferation|
|protein catabolic process|
|response to bacterium|
|perinuclear region of cytoplasm|
|positive regulation of cell death|
|chromatin organization|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|enzyme linked receptor protein signaling pathway|
|regulation of proteolysis|
|brain development|
|regulation of cell cycle process|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|head development|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|defense response to other organism|
|cellular lipid metabolic process|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of catabolic process|
|response to organonitrogen compound|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to nitrogen compound|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|response to abiotic stimulus|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|mitochondrion|
|proteolysis|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|cell cycle|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-2.16|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-1.89|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.73|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10882
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIRT2 Expression in NALM6 Cells: 5.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>