======= SIX2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SIX2
  * **<color #00a2e8>Official Name</color>**: SIX homeobox 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10736|10736]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NPC8|Q9NPC8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SIX2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SIX2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604994|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the vertebrate gene family which encode proteins homologous to the Drosophila 'sine oculis' homeobox protein. The encoded protein is a transcription factor which, like other members of this gene family, may be involved in limb or eye development. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. Also may be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Homeobox|
|Homeobox KN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mesenchymal stem cell proliferation|
|mesenchymal stem cell maintenance involved in nephron morphogenesis|
|condensed mesenchymal cell proliferation|
|positive regulation of chondrocyte proliferation|
|mesodermal cell fate specification|
|mesenchymal to epithelial transition involved in metanephros morphogenesis|
|mesenchymal cell differentiation involved in renal system development|
|mesenchymal cell differentiation involved in kidney development|
|metanephric renal vesicle morphogenesis|
|renal vesicle morphogenesis|
|renal vesicle development|
|mesodermal cell fate commitment|
|mesenchymal to epithelial transition|
|mesenchymal cell proliferation|
|cell differentiation involved in metanephros development|
|kidney mesenchyme development|
|embryonic digestive tract morphogenesis|
|middle ear morphogenesis|
|metanephric nephron morphogenesis|
|regulation of branching involved in ureteric bud morphogenesis|
|regulation of mesonephros development|
|mesodermal cell differentiation|
|metanephros morphogenesis|
|cell fate commitment involved in formation of primary germ layer|
|epithelial cell differentiation involved in kidney development|
|metanephric nephron development|
|embryonic digestive tract development|
|cell differentiation involved in kidney development|
|embryonic cranial skeleton morphogenesis|
|digestive tract morphogenesis|
|anterior/posterior axis specification|
|regulation of chondrocyte differentiation|
|stem cell proliferation|
|regulation of kidney development|
|regulation of morphogenesis of a branching structure|
|somatic stem cell population maintenance|
|cranial skeletal system development|
|nephron epithelium morphogenesis|
|nephron morphogenesis|
|mesoderm formation|
|mesoderm morphogenesis|
|regulation of cartilage development|
|transcription regulatory region sequence-specific DNA binding|
|chondrocyte differentiation|
|metanephros development|
|kidney morphogenesis|
|axis specification|
|cell fate specification|
|embryonic skeletal system morphogenesis|
|protein import into nucleus|
|nephron epithelium development|
|formation of primary germ layer|
|import into nucleus|
|ear morphogenesis|
|nephron development|
|mesoderm development|
|embryonic skeletal system development|
|kidney epithelium development|
|digestive tract development|
|stem cell population maintenance|
|maintenance of cell number|
|protein import|
|digestive system development|
|mesenchymal cell differentiation|
|gastrulation|
|protein localization to nucleus|
|cartilage development|
|regulation of morphogenesis of an epithelium|
|regulation of ossification|
|transcription factor complex|
|anterior/posterior pattern specification|
|ear development|
|mesenchyme development|
|connective tissue development|
|skeletal system morphogenesis|
|cell fate commitment|
|sensory organ morphogenesis|
|regulation of animal organ morphogenesis|
|nucleocytoplasmic transport|
|protein-containing complex binding|
|nuclear transport|
|kidney development|
|renal system development|
|embryonic organ morphogenesis|
|urogenital system development|
|transcription factor binding|
|regionalization|
|morphogenesis of an epithelium|
|establishment of protein localization to organelle|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|skeletal system development|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|sensory organ development|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|epithelial cell differentiation|
|negative regulation of cell differentiation|
|protein localization to organelle|
|tube development|
|anatomical structure formation involved in morphogenesis|
|positive regulation of cell population proliferation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|embryo development|
|intracellular protein transport|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|locomotion|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|regulation of cell differentiation|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.17|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-1.88|
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.82|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.71|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.77|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.9|
|[[:results:exp275|Citral 75μM R06 exp275]]|2.28|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SIX2 Expression in NALM6 Cells: -5.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>