======= SKA1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SKA1
  * **<color #00a2e8>Official Name</color>**: spindle and kinetochore associated complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220134|220134]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BD8|Q96BD8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKA1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKA1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616673|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020). {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:23085020}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1395|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|condensed chromosome outer kinetochore|
|spindle microtubule|
|mitotic spindle|
|regulation of microtubule polymerization or depolymerization|
|microtubule cytoskeleton|
|regulation of microtubule cytoskeleton organization|
|regulation of microtubule-based process|
|microtubule binding|
|chromosome segregation|
|cell division|
|regulation of cytoskeleton organization|
|mitotic cell cycle|
|regulation of organelle organization|
|cell cycle|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-4.01|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-3.63|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-3.18|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|-2.74|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-2.72|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-2.69|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.57|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|-2.34|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.33|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-2.29|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-2.16|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.08|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.05|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.82|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-1.79|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.77|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.77|
|[[:results:exp415|Trichostatin-A 0.06μM R07 exp415]]|-1.77|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|-1.73|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.72|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|1.73|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.76|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|1.96|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:ska3|SKA3]]|0.562|
|[[:human genes:k:kif18a|KIF18A]]|0.533|
|[[:human genes:v:vbp1|VBP1]]|0.507|
|[[:human genes:u:ube2c|UBE2C]]|0.498|
|[[:human genes:s:stmn1|STMN1]]|0.485|
|[[:human genes:s:ska2|SKA2]]|0.464|
|[[:human genes:p:pfdn5|PFDN5]]|0.454|
|[[:human genes:a:actr1a|ACTR1A]]|0.418|
|[[:human genes:u:ube2s|UBE2S]]|0.418|
|[[:human genes:a:arl2|ARL2]]|0.408|
|[[:human genes:t:tubb4b|TUBB4B]]|0.405|
|[[:human genes:a:anapc13|ANAPC13]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 30/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|0/26|
|breast|1/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|4/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|5/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2693
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKA1 Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>