======= SKAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SKAP1
  * **<color #00a2e8>Official Name</color>**: src kinase associated phosphoprotein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8631|8631]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WV1|Q86WV1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604969|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SH3 2|
|PH|
|SH3 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell-cell adhesion mediated by integrin|
|positive regulation of integrin activation|
|regulation of cell-cell adhesion mediated by integrin|
|regulation of integrin activation|
|positive regulation of heterotypic cell-cell adhesion|
|microtubule plus-end binding|
|microtubule plus-end|
|positive regulation of cell adhesion mediated by integrin|
|regulation of heterotypic cell-cell adhesion|
|plasma membrane raft|
|SH2 domain binding|
|immunological synapse|
|cellular response to epidermal growth factor stimulus|
|regulation of cell adhesion mediated by integrin|
|response to epidermal growth factor|
|positive regulation of cell-matrix adhesion|
|SH3/SH2 adaptor activity|
|protein phosphatase binding|
|ruffle|
|positive regulation of adaptive immune response|
|regulation of cell-matrix adhesion|
|positive regulation of cell-substrate adhesion|
|T cell receptor complex|
|SH3 domain binding|
|regulation of adaptive immune response|
|cell-cell junction|
|T cell receptor signaling pathway|
|protein localization to plasma membrane|
|regulation of cell-substrate adhesion|
|positive regulation of leukocyte cell-cell adhesion|
|protein localization to cell periphery|
|positive regulation of protein complex assembly|
|positive regulation of cell-cell adhesion|
|protein-containing complex binding|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|immune response-activating cell surface receptor signaling pathway|
|regulation of protein complex assembly|
|protein kinase binding|
|microtubule cytoskeleton organization|
|protein localization to membrane|
|immune response-regulating cell surface receptor signaling pathway|
|cellular response to growth factor stimulus|
|positive regulation of cellular component biogenesis|
|response to growth factor|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|adaptive immune response|
|activation of immune response|
|microtubule-based process|
|regulation of cell adhesion|
|positive regulation of immune response|
|protein homodimerization activity|
|regulation of cellular component biogenesis|
|cell migration|
|localization of cell|
|cell motility|
|cytoskeleton organization|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of cellular component organization|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|locomotion|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|positive regulation of RNA metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.88|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.72|
|[[:results:exp114|A-196 10μM R03 exp114]]|1.74|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|1.8|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.82|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.92|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.06|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3308
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKAP1 Expression in NALM6 Cells: -0.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>