======= SKIV2L2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: MTREX
  * **<color #00a2e8>Official Name</color>**: Mtr4 exosome RNA helicase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23517|23517]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P42285|P42285]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SKIV2L2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SKIV2L2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618122|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:27871484}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|DSHCT|
|DEAD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAMP complex|
|nuclear exosome (RNase complex)|
|exosome (RNase complex)|
|maturation of 5.8S rRNA|
|RNA helicase activity|
|catalytic step 2 spliceosome|
|rRNA processing|
|rRNA metabolic process|
|RNA catabolic process|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|ribosome biogenesis|
|RNA splicing, via transesterification reactions|
|nucleobase-containing compound catabolic process|
|ncRNA processing|
|RNA splicing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|mRNA processing|
|organic cyclic compound catabolic process|
|mRNA metabolic process|
|nucleolus|
|RNA processing|
|cellular macromolecule catabolic process|
|macromolecule catabolic process|
|RNA binding|
|ATP binding|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp211|AICAR 240μM R05 exp211]]|-2.7|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-2.41|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-2.4|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.4|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.39|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.36|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-2.34|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.22|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.16|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|-2.15|
|[[:results:exp17|DABN 20μM R00 exp17]]|-1.91|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|-1.88|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.85|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-1.83|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-1.82|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.81|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.72|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.71|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-1.7|
|[[:results:exp302|35°C R06 exp302]]|1.71|
|[[:results:exp123|GSK-LSD1 10μM R03 exp123]]|1.71|
|[[:results:exp210|LB-100 2μM R05 exp210]]|1.73|
|[[:results:exp148|SB202190 10μM R03 exp148]]|1.76|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|1.78|
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|1.85|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|1.87|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|1.88|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.93|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|2.02|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.03|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|2.05|
|[[:results:exp285|GW501516 25μM R06 exp285]]|2.17|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.27|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|2.69|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:o:osbp|OSBP]]|0.484|
|[[:human genes:t:tsg101|TSG101]]|0.464|
|[[:human genes:t:tpx2|TPX2]]|0.46|
|[[:human genes:p:psmb4|PSMB4]]|0.458|
|[[:human genes:p:psmb2|PSMB2]]|0.438|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.436|
|[[:human genes:p:psma6|PSMA6]]|0.434|
|[[:human genes:s:sap30bp|SAP30BP]]|0.433|
|[[:human genes:r:rrp7a|RRP7A]]|0.428|
|[[:human genes:m:mtch2|MTCH2]]|0.426|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.425|
|[[:human genes:c:cdt1|CDT1]]|0.423|
|[[:human genes:g:golga8o|GOLGA8O]]|0.422|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.421|
|[[:human genes:a:aatf|AATF]]|0.419|
|[[:human genes:c:cln6|CLN6]]|0.417|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.416|
|[[:human genes:c:chaf1a|CHAF1A]]|0.416|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.41|
|[[:human genes:c:copa|COPA]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.405|
|[[:human genes:c:cactin|CACTIN]]|0.404|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.403|
|[[:human genes:g:gid4|GID4]]|0.4|
|[[:human genes:t:tfip11|TFIP11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 726/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|27/28|
|bone|26/26|
|breast|33/33|
|central nervous system|54/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|19/20|
|lung|73/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 580
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SKIV2L2 Expression in NALM6 Cells: 7.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>