======= SLC11A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC11A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 11 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6556|6556]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49279|P49279]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC11A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC11A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600266|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nramp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|divalent metal ion export|
|MHC class II biosynthetic process|
|interleukin-3 production|
|cellular cadmium ion homeostasis|
|metal ion:proton antiporter activity|
|nitrite transport|
|cadmium ion transmembrane transporter activity|
|cadmium ion homeostasis|
|transition metal ion transmembrane transporter activity|
|manganese ion transmembrane transporter activity|
|cadmium ion transport|
|cadmium ion transmembrane transport|
|T cell proliferation involved in immune response|
|manganese ion transmembrane transport|
|L-arginine transport|
|iron ion transmembrane transporter activity|
|positive regulation of dendritic cell antigen processing and presentation|
|arginine transport|
|multicellular organismal iron ion homeostasis|
|positive regulation of antigen processing and presentation|
|interleukin-2 production|
|T cell cytokine production|
|regulation of dendritic cell antigen processing and presentation|
|manganese ion transport|
|basic amino acid transport|
|iron ion transmembrane transport|
|regulation of antigen processing and presentation|
|positive regulation of T-helper 1 type immune response|
|respiratory burst|
|vacuolar acidification|
|cytokine production involved in immune response|
|defense response to protozoan|
|response to protozoan|
|regulation of T-helper 1 type immune response|
|T cell proliferation|
|T cell mediated immunity|
|mRNA stabilization|
|intracellular pH reduction|
|pH reduction|
|RNA stabilization|
|macrophage activation|
|negative regulation of mRNA catabolic process|
|L-amino acid transport|
|negative regulation of RNA catabolic process|
|ficolin-1-rich granule membrane|
|cellular iron ion homeostasis|
|positive regulation of interferon-gamma production|
|T cell activation involved in immune response|
|positive regulation of phagocytosis|
|iron ion transport|
|tertiary granule membrane|
|phagocytic vesicle membrane|
|cell redox homeostasis|
|negative regulation of mRNA metabolic process|
|iron ion homeostasis|
|defense response to Gram-negative bacterium|
|lymphocyte proliferation|
|regulation of intracellular pH|
|mononuclear cell proliferation|
|regulation of cellular pH|
|regulation of phagocytosis|
|leukocyte proliferation|
|regulation of pH|
|regulation of interferon-gamma production|
|positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|positive regulation of adaptive immune response|
|cellular transition metal ion homeostasis|
|cellular monovalent inorganic cation homeostasis|
|lymphocyte activation involved in immune response|
|antimicrobial humoral response|
|amino acid transport|
|late endosome membrane|
|transition metal ion transport|
|late endosome|
|transition metal ion homeostasis|
|monovalent inorganic cation homeostasis|
|regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|drug transport|
|cytokine production|
|inorganic anion transport|
|regulation of adaptive immune response|
|regulation of mRNA stability|
|production of molecular mediator of immune response|
|response to interferon-gamma|
|regulation of RNA stability|
|antigen processing and presentation of peptide antigen|
|regulation of mRNA catabolic process|
|antigen processing and presentation|
|T cell activation|
|lysosome|
|negative regulation of cellular catabolic process|
|lymphocyte mediated immunity|
|negative regulation of cytokine production|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|carboxylic acid transport|
|organic acid transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|negative regulation of catabolic process|
|response to lipopolysaccharide|
|multicellular organismal homeostasis|
|response to molecule of bacterial origin|
|regulation of mRNA metabolic process|
|activation of protein kinase activity|
|phagocytosis|
|defense response to bacterium|
|humoral immune response|
|lymphocyte activation|
|positive regulation of cytokine production|
|organic anion transport|
|cellular divalent inorganic cation homeostasis|
|wound healing|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|posttranscriptional regulation of gene expression|
|positive regulation of protein kinase activity|
|regulation of vesicle-mediated transport|
|cell population proliferation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|response to wounding|
|positive regulation of kinase activity|
|anion transport|
|myeloid leukocyte activation|
|adaptive immune response|
|cation transmembrane transport|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|positive regulation of transferase activity|
|response to bacterium|
|regulation of cytokine production|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|innate immune response|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|cation transport|
|regulation of cellular catabolic process|
|response to lipid|
|positive regulation of immune response|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular homeostasis|
|leukocyte activation|
|ion transmembrane transport|
|defense response to other organism|
|regulation of transferase activity|
|positive regulation of transport|
|regulation of catabolic process|
|secretion by cell|
|positive regulation of protein phosphorylation|
|response to drug|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|secretion|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|transmembrane transport|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|negative regulation of RNA metabolic process|
|defense response|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp170|Metformin 100 to 150μM on day4 R04 exp170]]|-1.72|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11763
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.12 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC11A1 Expression in NALM6 Cells: 4.12'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>