======= SLC11A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC11A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 11 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=4891|4891]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49281|P49281]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC11A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC11A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600523|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nramp|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nickel cation transmembrane transport|
|nickel cation transport|
|paraferritin complex|
|lead ion transmembrane transporter activity|
|nickel cation transmembrane transporter activity|
|cobalt ion transmembrane transporter activity|
|lead ion transport|
|transition metal ion transmembrane transporter activity|
|cadmium ion transmembrane transporter activity|
|solute:proton symporter activity|
|ferrous iron transmembrane transporter activity|
|manganese ion transmembrane transporter activity|
|cadmium ion transmembrane transport|
|iron import into cell|
|cadmium ion transport|
|copper ion transmembrane transporter activity|
|cobalt ion transport|
|cadmium ion binding|
|manganese ion transmembrane transport|
|copper ion transmembrane transport|
|iron ion transmembrane transporter activity|
|multicellular organismal iron ion homeostasis|
|manganese ion transport|
|vacuole|
|basal part of cell|
|iron ion transmembrane transport|
|copper ion transport|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|erythrocyte development|
|response to iron ion|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|brush border membrane|
|extracellular vesicle|
|dendrite morphogenesis|
|myeloid cell development|
|tetrapyrrole metabolic process|
|cellular iron ion homeostasis|
|pigment metabolic process|
|apical part of cell|
|iron ion transport|
|iron ion homeostasis|
|erythrocyte differentiation|
|erythrocyte homeostasis|
|dendrite development|
|cellular transition metal ion homeostasis|
|myeloid cell homeostasis|
|recycling endosome|
|late endosome membrane|
|transition metal ion transport|
|transition metal ion homeostasis|
|proton transmembrane transport|
|mitochondrial outer membrane|
|homeostasis of number of cells|
|cofactor biosynthetic process|
|myeloid cell differentiation|
|cytoplasmic vesicle|
|early endosome|
|learning or memory|
|divalent metal ion transport|
|cognition|
|lysosomal membrane|
|divalent inorganic cation transport|
|apical plasma membrane|
|multicellular organismal homeostasis|
|response to hypoxia|
|response to decreased oxygen levels|
|response to metal ion|
|response to oxygen levels|
|monovalent inorganic cation transport|
|cell morphogenesis involved in neuron differentiation|
|cofactor metabolic process|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|response to inorganic substance|
|hemopoiesis|
|cellular metal ion homeostasis|
|cell morphogenesis involved in differentiation|
|inorganic cation transmembrane transport|
|behavior|
|hematopoietic or lymphoid organ development|
|cation transmembrane transport|
|cell surface|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|immune system development|
|neuron projection development|
|import into cell|
|perinuclear region of cytoplasm|
|cation homeostasis|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|ion homeostasis|
|neuron development|
|cellular component morphogenesis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|neuron differentiation|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|mitochondrion|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|nervous system process|
|integral component of plasma membrane|
|organonitrogen compound biosynthetic process|
|generation of neurons|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|establishment of localization in cell|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.83|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.97|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.94|
|[[:results:exp534|Trientine 500μM R08 exp534]]|-1.88|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.84|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|-1.81|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.78|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-1.76|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.7|
|[[:results:exp281|Disulfiram 4.3μM R06 exp281]]|1.71|
|[[:results:exp293|Myriocin 25μM R06 exp293]]|1.72|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.74|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|1.81|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|1.98|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.01|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.26|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cyb561a3|CYB561A3]]|0.422|
|[[:human genes:g:glrx3|GLRX3]]|0.414|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10556
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC11A2 Expression in NALM6 Cells: 6.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>