======= SLC12A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC12A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 12 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6558|6558]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55011|P55011]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC12A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC12A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600840|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Electrically silent transporter system. Mediates sodium and chloride reabsorption. Plays a vital role in the regulation of ionic balance and cell volume.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
|AA permease N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell volume|
|sodium:chloride symporter activity|
|sodium:potassium:chloride symporter activity|
|transepithelial ammonium transport|
|transepithelial chloride transport|
|sodium ion transmembrane transporter activity|
|ammonium transmembrane transporter activity|
|potassium:chloride symporter activity|
|T cell chemotaxis|
|chloride ion homeostasis|
|ammonium transmembrane transport|
|transepithelial transport|
|hyperosmotic response|
|gamma-aminobutyric acid signaling pathway|
|monovalent inorganic anion homeostasis|
|cell volume homeostasis|
|T cell migration|
|potassium ion homeostasis|
|sodium ion homeostasis|
|potassium ion import across plasma membrane|
|lymphocyte chemotaxis|
|ammonium transport|
|extracellular vesicle|
|anion homeostasis|
|lymphocyte migration|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|response to osmotic stress|
|chloride transmembrane transport|
|response to chemokine|
|cellular response to chemokine|
|sodium ion transmembrane transport|
|import across plasma membrane|
|chloride transport|
|inorganic anion transmembrane transport|
|monovalent inorganic cation homeostasis|
|leukocyte chemotaxis|
|sodium ion transport|
|inorganic anion transport|
|potassium ion transmembrane transport|
|potassium ion transport|
|regulation of cell size|
|cell chemotaxis|
|anion transmembrane transport|
|aging|
|apical plasma membrane|
|regulation of cellular component size|
|leukocyte migration|
|monovalent inorganic cation transport|
|protein kinase binding|
|regulation of anatomical structure size|
|chemotaxis|
|taxis|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion homeostasis|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|cell migration|
|cellular response to cytokine stimulus|
|cell motility|
|localization of cell|
|response to cytokine|
|chemical homeostasis|
|response to abiotic stimulus|
|transmembrane transport|
|locomotion|
|G protein-coupled receptor signaling pathway|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|homeostatic process|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-2.3|
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-2.1|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.72|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|1.74|
|[[:results:exp539|42°C R08 exp539]]|1.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.82|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.14|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.17|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.18|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.22|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.91|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3.1|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|5.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8039
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC12A2 Expression in NALM6 Cells: 6.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>