======= SLC1A6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC1A6
  * **<color #00a2e8>Official Name</color>**: solute carrier family 1 member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6511|6511]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P48664|P48664]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC1A6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC1A6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600637|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7791878). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (Probable). {ECO:0000250|UniProtKB:O35921, ECO:0000269|PubMed:7791878, ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|SDF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high-affinity glutamate transmembrane transporter activity|
|L-aspartate transmembrane transporter activity|
|L-aspartate transmembrane transport|
|L-glutamate import across plasma membrane|
|aspartate transmembrane transport|
|L-glutamate import|
|amino acid import across plasma membrane|
|L-glutamate transmembrane transport|
|amino acid import|
|C4-dicarboxylate transport|
|glutamate secretion|
|neurotransmitter uptake|
|L-alpha-amino acid transmembrane transport|
|acidic amino acid transport|
|intermediate filament cytoskeleton|
|integral component of presynaptic membrane|
|L-amino acid transport|
|drug transmembrane transport|
|amino acid transmembrane transport|
|dicarboxylic acid transport|
|acid secretion|
|import across plasma membrane|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|drug transport|
|neurotransmitter transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|regulation of membrane potential|
|trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|anion transport|
|import into cell|
|ion transmembrane transport|
|Golgi apparatus|
|secretion by cell|
|response to drug|
|export from cell|
|cell-cell signaling|
|secretion|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.82|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ruvbl2|RUVBL2]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11756
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC1A6 Expression in NALM6 Cells: 2.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>