======= SLC20A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC20A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 20 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6574|6574]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WUM9|Q8WUM9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC20A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC20A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/137570|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport, such as absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification. {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:7966619, ECO:0000269|PubMed:8041748}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PHO4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|high-affinity inorganic phosphate:sodium symporter activity|
|sodium:inorganic phosphate symporter activity|
|inorganic phosphate transmembrane transporter activity|
|sodium:phosphate symporter activity|
|phosphate ion transmembrane transport|
|phosphate ion transport|
|sodium ion transmembrane transport|
|biomineralization|
|biomineral tissue development|
|inorganic anion transmembrane transport|
|sodium ion transport|
|inorganic anion transport|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|signaling receptor activity|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|anion transmembrane transport|
|monovalent inorganic cation transport|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|metal ion transport|
|inorganic ion transmembrane transport|
|cation transport|
|ion transmembrane transport|
|positive regulation of intracellular signal transduction|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.9|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.76|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|1.71|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|1.72|
|[[:results:exp277|Curcumin 6.5μM R06 exp277]]|1.73|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|1.74|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|1.76|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|1.78|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.78|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|1.8|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.81|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|1.84|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.85|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.87|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.89|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|1.95|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.98|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|2.05|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.08|
|[[:results:exp211|AICAR 240μM R05 exp211]]|2.36|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.44|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.56|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|2.69|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|3.5|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|8.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mpp6|MPP6]]|0.594|
|[[:human genes:h:hars|HARS]]|0.444|
|[[:human genes:t:tmem208|TMEM208]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 12/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 993
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC20A1 Expression in NALM6 Cells: 7.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>