======= SLC22A14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC22A14
  * **<color #00a2e8>Official Name</color>**: solute carrier family 22 member 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9389|9389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y267|Q9Y267]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC22A14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC22A14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604048|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|MFS 1|
|Sugar tr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|organic cation transmembrane transporter activity|
|organic cation transport|
|cation transport|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|-2.55|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.44|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.26|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.21|
|[[:results:exp379|MSC2530818 10μM R07 exp379]]|-2.21|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.14|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-2.08|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|-2|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.96|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.93|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.91|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|-1.83|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|-1.78|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.76|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.74|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|-1.74|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.71|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|-1.71|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|1.78|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11830
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.13 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC22A14 Expression in NALM6 Cells: -3.13'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>