======= SLC25A33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC25A33
  * **<color #00a2e8>Official Name</color>**: solute carrier family 25 member 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84275|84275]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BSK2|Q9BSK2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC25A33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC25A33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610816|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria (PubMed:25320081). Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (PubMed:25320081). Also transports guanine but not adenine (deoxy)nucleotides (PubMed:25320081). Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10- phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate) (PubMed:25320081). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (PubMed:20453889). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (PubMed:20453889, PubMed:17596519). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (PubMed:14715278). {ECO:0000269|PubMed:14715278, ECO:0000269|PubMed:17596519, ECO:0000269|PubMed:20453889, ECO:0000269|PubMed:25320081}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Mito carr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondria-nucleus signaling pathway|
|pyrimidine nucleotide transport|
|pyrimidine nucleotide import into mitochondrion|
|pyrimidine nucleotide transmembrane transporter activity|
|nucleotide transmembrane transport|
|respiratory chain complex III assembly|
|cellular response to insulin-like growth factor stimulus|
|mitochondrial respiratory chain complex III assembly|
|pyrimidine-containing compound transmembrane transport|
|mitochondrial transcription|
|mitochondrial genome maintenance|
|nucleotide transport|
|regulation of oxidative phosphorylation|
|cytochrome complex assembly|
|mitochondrial RNA metabolic process|
|regulation of mitochondrial membrane potential|
|regulation of reactive oxygen species biosynthetic process|
|mitochondrial transmembrane transport|
|mitochondrial respiratory chain complex assembly|
|mitochondrial membrane|
|regulation of cell cycle arrest|
|regulation of ATP metabolic process|
|organophosphate ester transport|
|mitochondrial gene expression|
|regulation of generation of precursor metabolites and energy|
|cellular response to insulin stimulus|
|positive regulation of cell growth|
|regulation of reactive oxygen species metabolic process|
|mitochondrial transport|
|response to insulin|
|nucleobase-containing compound transport|
|positive regulation of growth|
|cellular response to peptide hormone stimulus|
|cellular response to peptide|
|response to peptide hormone|
|mitochondrial inner membrane|
|regulation of cell growth|
|regulation of membrane potential|
|mitochondrion organization|
|response to peptide|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|cellular response to nitrogen compound|
|regulation of growth|
|regulation of cell cycle process|
|cellular protein-containing complex assembly|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.34|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.25|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-1.86|
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-1.82|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.75|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-1.71|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|-1.71|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.58|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|3.14|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|4.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox7a2l|COX7A2L]]|0.448|
|[[:human genes:s:slc25a36|SLC25A36]]|0.446|
|[[:human genes:m:mrs2|MRS2]]|0.435|
|[[:human genes:p:polr2j3|POLR2J3]]|0.431|
|[[:human genes:n:nme6|NME6]]|0.425|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19080
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.23 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC25A33 Expression in NALM6 Cells: 5.23'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>