======= SLC27A5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC27A5
  * **<color #00a2e8>Official Name</color>**: solute carrier family 27 member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10998|10998]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2P5|Q9Y2P5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC27A5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC27A5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603314|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, also activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. {ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:11980911}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AMP-binding|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|long-chain fatty acid import across plasma membrane|
|cholate-CoA ligase activity|
|triglyceride mobilization|
|fatty acid transmembrane transporter activity|
|very long-chain fatty acid-CoA ligase activity|
|ketone body biosynthetic process|
|lipid import into cell|
|long-chain fatty acid import into cell|
|cellular ketone body metabolic process|
|long-chain fatty acid transporter activity|
|ketone body metabolic process|
|long-chain fatty acid-CoA ligase activity|
|fatty acid transmembrane transport|
|bile acid biosynthetic process|
|bile acid and bile salt transport|
|very long-chain fatty acid metabolic process|
|basal plasma membrane|
|bile acid metabolic process|
|long-chain fatty acid transport|
|fatty acid transport|
|triglyceride metabolic process|
|fatty acid derivative biosynthetic process|
|import across plasma membrane|
|acylglycerol metabolic process|
|neutral lipid metabolic process|
|integral component of endoplasmic reticulum membrane|
|long-chain fatty acid metabolic process|
|steroid biosynthetic process|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|monocarboxylic acid transport|
|organic hydroxy compound transport|
|fatty acid derivative metabolic process|
|organic hydroxy compound biosynthetic process|
|monocarboxylic acid biosynthetic process|
|steroid metabolic process|
|protein-containing complex binding|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|lipid transport|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|lipid localization|
|fatty acid metabolic process|
|glycerolipid metabolic process|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|organic anion transport|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|lipid biosynthetic process|
|anion transport|
|small molecule biosynthetic process|
|protein-containing complex|
|import into cell|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|cellular lipid metabolic process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|organic acid metabolic process|
|lipid metabolic process|
|transmembrane transport|
|organic cyclic compound biosynthetic process|
|ion transport|
|ATP binding|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp115|A-366 10μM R03 exp115]]|-2.21|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6494
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC27A5 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>