======= SLC29A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC29A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 29 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3177|3177]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q14542|Q14542]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC29A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC29A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602110|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269|PubMed:9396714}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Nucleoside tran|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|hypoxanthine transport|
|thymine transport|
|guanine transport|
|uridine transport|
|pyrimidine nucleoside transport|
|adenine transport|
|pyrimidine nucleobase transport|
|purine nucleobase transport|
|nucleoside transport|
|nucleoside transmembrane transport|
|nucleoside transmembrane transporter activity|
|nucleobase transport|
|neurotransmitter reuptake|
|neurotransmitter uptake|
|carbohydrate derivative transport|
|presynapse|
|neurotransmitter transport|
|basolateral plasma membrane|
|nuclear membrane|
|nucleobase-containing compound transport|
|regulation of neurotransmitter levels|
|import into cell|
|nucleolus|
|transmembrane transport|
|integral component of plasma membrane|
|establishment of localization in cell|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp140|Nicotinate 1000μM R03 exp140]]|-2.15|
|[[:results:exp285|GW501516 25μM R06 exp285]]|-1.94|
|[[:results:exp292|Menadione 5μM R06 exp292]]|-1.94|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-1.88|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.74|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|-1.74|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.71|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|1.72|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.74|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.79|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10357
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC29A2 Expression in NALM6 Cells: 4.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>