======= SLC31A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC31A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 31 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1317|1317]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15431|O15431]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC31A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC31A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603085|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  High-affinity, saturable copper transporter involved in dietary copper uptake. {ECO:0000269|PubMed:11734551}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ctr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|copper ion import across plasma membrane|
|plasma membrane copper ion transport|
|copper ion transmembrane transporter activity|
|cellular response to cisplatin|
|copper ion transmembrane transport|
|copper ion import|
|response to cisplatin|
|cellular copper ion homeostasis|
|copper ion transport|
|copper ion homeostasis|
|drug transmembrane transport|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|response to antineoplastic agent|
|import across plasma membrane|
|cellular transition metal ion homeostasis|
|recycling endosome|
|transition metal ion transport|
|late endosome|
|transition metal ion homeostasis|
|drug transport|
|cellular response to toxic substance|
|neuronal cell body|
|cellular response to drug|
|response to toxic substance|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|cellular homeostasis|
|ion transmembrane transport|
|response to drug|
|identical protein binding|
|chemical homeostasis|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.85|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.73|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|1.75|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.8|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.86|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|1.93|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.01|
|[[:results:exp436|Dynasore 7μM R08 exp436]]|2.07|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.18|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|2.18|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.29|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.32|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.486|
|[[:human genes:c:coa6|COA6]]|0.457|
|[[:human genes:c:coa3|COA3]]|0.45|
|[[:human genes:c:cox18|COX18]]|0.45|
|[[:human genes:m:mettl17|METTL17]]|0.449|
|[[:human genes:m:mrpl47|MRPL47]]|0.443|
|[[:human genes:n:ndufs5|NDUFS5]]|0.439|
|[[:human genes:m:mrps12|MRPS12]]|0.438|
|[[:human genes:m:mtpap|MTPAP]]|0.434|
|[[:human genes:c:cox6b1|COX6B1]]|0.425|
|[[:human genes:m:mrpl49|MRPL49]]|0.419|
|[[:human genes:l:lrpprc|LRPPRC]]|0.412|
|[[:human genes:p:ptcd3|PTCD3]]|0.411|
|[[:human genes:v:vars2|VARS2]]|0.409|
|[[:human genes:m:mrps34|MRPS34]]|0.407|
|[[:human genes:m:mrps27|MRPS27]]|0.405|
|[[:human genes:c:clpp|CLPP]]|0.403|
|[[:human genes:n:nars2|NARS2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1667
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC31A1 Expression in NALM6 Cells: 5.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>