======= SLC33A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC33A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 33 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9197|9197]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00400|O00400]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC33A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC33A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603690|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable acetyl-CoA transporter necessary for O- acetylation of gangliosides (PubMed:9096318). Negatively regulates BMP signaling (PubMed:25402622). {ECO:0000269|PubMed:25402622, ECO:0000269|PubMed:9096318}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Acatn|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|acetyl-CoA transport|
|acetyl-CoA transmembrane transporter activity|
|fatty-acyl-CoA transport|
|thioester transport|
|solute:proton symporter activity|
|coenzyme transport|
|adenine nucleotide transport|
|purine ribonucleotide transport|
|purine nucleotide transport|
|nucleotide transport|
|sulfur compound transport|
|cofactor transport|
|SMAD protein signal transduction|
|carbohydrate derivative transport|
|BMP signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|organophosphate ester transport|
|proton transmembrane transport|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|nucleobase-containing compound transport|
|monovalent inorganic cation transport|
|organic anion transport|
|cellular response to growth factor stimulus|
|response to growth factor|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|Golgi membrane|
|inorganic ion transmembrane transport|
|enzyme linked receptor protein signaling pathway|
|cation transport|
|endoplasmic reticulum membrane|
|ion transmembrane transport|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|amide transport|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-1.86|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.73|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.72|
|[[:results:exp292|Menadione 5μM R06 exp292]]|1.75|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.84|
|[[:results:exp248|UM0131023 0.05μM R05 exp248]]|1.88|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.38|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:manf|MANF]]|0.506|
|[[:human genes:d:dnajc3|DNAJC3]]|0.459|
|[[:human genes:d:dnajb11|DNAJB11]]|0.446|
|[[:human genes:d:derl1|DERL1]]|0.425|
|[[:human genes:a:alg9|ALG9]]|0.414|
|[[:human genes:s:sec63|SEC63]]|0.405|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2036
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC33A1 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>