======= SLC34A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC34A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 34 member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6569|6569]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06495|Q06495]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC34A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC34A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the type II sodium-phosphate cotransporter family. Mutations in this gene are associated with hypophosphatemia nephrolithiasis/osteoporosis 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane. Probably mediates 70-80% of the apical influx. {ECO:0000269|PubMed:26047794, ECO:0000269|PubMed:8327470}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na Pi cotrans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of phosphate transmembrane transport|
|indole metabolic process|
|positive regulation of phosphate transmembrane transport|
|gentamycin metabolic process|
|arsenate ion transmembrane transport|
|positive regulation of sodium-dependent phosphate transport|
|positive regulation of inorganic anion transmembrane transport|
|cellular response to staurosporine|
|sodium-dependent phosphate transmembrane transporter activity|
|response to staurosporine|
|sodium-dependent phosphate transport|
|regulation of sodium-dependent phosphate transport|
|regulation of inorganic anion transmembrane transport|
|dentinogenesis|
|positive regulation of anion transmembrane transport|
|sodium:phosphate symporter activity|
|cellular phosphate ion homeostasis|
|cellular trivalent inorganic anion homeostasis|
|regulation of phosphate transport|
|cellular divalent inorganic anion homeostasis|
|cellular response to parathyroid hormone stimulus|
|aminoglycoside antibiotic metabolic process|
|response to mercury ion|
|trivalent inorganic anion homeostasis|
|cellular anion homeostasis|
|phosphate ion homeostasis|
|response to parathyroid hormone|
|cellular monovalent inorganic anion homeostasis|
|divalent inorganic anion homeostasis|
|tricarboxylic acid metabolic process|
|positive regulation of membrane potential|
|sodium ion import across plasma membrane|
|response to potassium ion|
|phosphate ion transmembrane transport|
|response to vitamin A|
|response to magnesium ion|
|glycoside metabolic process|
|phosphate ion transport|
|response to lead ion|
|indole-containing compound metabolic process|
|response to thyroid hormone|
|monovalent inorganic anion homeostasis|
|regulation of anion transmembrane transport|
|response to growth hormone|
|cellular response to alkaloid|
|positive regulation of anion transport|
|brush border|
|brush border membrane|
|anion homeostasis|
|response to cadmium ion|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|mitotic spindle|
|odontogenesis of dentin-containing tooth|
|response to vitamin|
|PDZ domain binding|
|sodium ion transmembrane transport|
|regulation of anion transport|
|import across plasma membrane|
|antibiotic metabolic process|
|inorganic anion transmembrane transport|
|polyol metabolic process|
|response to alkaloid|
|odontogenesis|
|cellular response to ammonium ion|
|glycosyl compound metabolic process|
|response to estradiol|
|vesicle|
|sodium ion transport|
|positive regulation of ion transmembrane transport|
|inorganic anion transport|
|response to ammonium ion|
|cellular response to metal ion|
|positive regulation of transmembrane transport|
|response to nutrient|
|cellular response to inorganic substance|
|membrane raft|
|ossification|
|protein-containing complex binding|
|kidney development|
|endosome|
|positive regulation of ion transport|
|anion transmembrane transport|
|renal system development|
|alcohol metabolic process|
|apical plasma membrane|
|urogenital system development|
|protein homooligomerization|
|response to metal ion|
|glycoprotein metabolic process|
|response to peptide hormone|
|monovalent inorganic cation transport|
|nuclear speck|
|regulation of membrane potential|
|organic hydroxy compound metabolic process|
|response to peptide|
|regulation of ion transmembrane transport|
|response to nutrient levels|
|drug metabolic process|
|protein complex oligomerization|
|response to extracellular stimulus|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|anion transport|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|cation transport|
|response to lipid|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|carboxylic acid metabolic process|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|animal organ morphogenesis|
|positive regulation of transport|
|response to organonitrogen compound|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|chemical homeostasis|
|cellular response to endogenous stimulus|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|homeostatic process|
|small molecule metabolic process|
|protein-containing complex subunit organization|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.03|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.419|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC34A1 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>