======= SLC39A10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC39A10
  * **<color #00a2e8>Official Name</color>**: solute carrier family 39 member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57181|57181]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9ULF5|Q9ULF5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC39A10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC39A10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608733|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a zinc-influx transporter. {ECO:0000269|PubMed:17359283}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Zip|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of protein tyrosine phosphatase activity|
|regulation of protein tyrosine phosphatase activity|
|zinc ion import across plasma membrane|
|positive regulation of B cell receptor signaling pathway|
|negative regulation of B cell apoptotic process|
|regulation of B cell apoptotic process|
|zinc ion transmembrane transporter activity|
|positive regulation of phosphoprotein phosphatase activity|
|zinc ion transmembrane transport|
|positive regulation of antigen receptor-mediated signaling pathway|
|regulation of B cell receptor signaling pathway|
|zinc ion transport|
|negative regulation of lymphocyte apoptotic process|
|cellular zinc ion homeostasis|
|positive regulation of phosphatase activity|
|zinc ion homeostasis|
|positive regulation of B cell proliferation|
|positive regulation of protein dephosphorylation|
|negative regulation of leukocyte apoptotic process|
|regulation of lymphocyte apoptotic process|
|positive regulation of dephosphorylation|
|regulation of B cell proliferation|
|regulation of antigen receptor-mediated signaling pathway|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|regulation of leukocyte apoptotic process|
|import across plasma membrane|
|cellular transition metal ion homeostasis|
|regulation of phosphoprotein phosphatase activity|
|transition metal ion transport|
|positive regulation of lymphocyte proliferation|
|transition metal ion homeostasis|
|positive regulation of mononuclear cell proliferation|
|positive regulation of leukocyte proliferation|
|regulation of protein dephosphorylation|
|positive regulation of B cell activation|
|regulation of phosphatase activity|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|regulation of dephosphorylation|
|regulation of leukocyte proliferation|
|divalent metal ion transport|
|divalent inorganic cation transport|
|positive regulation of lymphocyte activation|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of lymphocyte activation|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of leukocyte activation|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|regulation of cell activation|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|import into cell|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|positive regulation of hydrolase activity|
|ion homeostasis|
|cation transport|
|positive regulation of immune response|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|ion transmembrane transport|
|negative regulation of cell death|
|chemical homeostasis|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|regulation of immune response|
|positive regulation of immune system process|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|transmembrane transport|
|ion transport|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of immune system process|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-3.02|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-2.87|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.81|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2.65|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-2.55|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|-2.54|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.41|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.35|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-2.12|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.09|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.93|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-1.89|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-1.89|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.88|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.79|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|-1.76|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.73|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|1.74|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.77|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|1.81|
|[[:results:exp539|42°C R08 exp539]]|1.86|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.93|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.93|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.94|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.96|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.96|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.06|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.09|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.1|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.21|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.28|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.37|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.39|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|2.48|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.6|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.72|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|2.73|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.75|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.88|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|3.16|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|3.43|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|5.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|8.5|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 27/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|0/26|
|breast|5/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|1/20|
|lung|3/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11520
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC39A10 Expression in NALM6 Cells: 5.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>