======= SLC3A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC3A2
  * **<color #00a2e8>Official Name</color>**: solute carrier family 3 member 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6520|6520]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P08195|P08195]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC3A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC3A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/158070|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier. When associated with LAPTM4B, recruits SLC3A2 and SLC7A5 to lysosomes to promote leucine uptake into these organelles and is required for mTORC1 activation (PubMed:25998567). {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:11389679, ECO:0000269|PubMed:11557028, ECO:0000269|PubMed:11564694, ECO:0000269|PubMed:11742812, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12225859, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15980244, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:9751058, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Alpha-amylase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-leucine import across plasma membrane|
|leucine import across plasma membrane|
|amino acid transport complex|
|leucine transport|
|tryptophan transport|
|calcium:sodium antiporter activity|
|branched-chain amino acid transport|
|neutral amino acid transmembrane transporter activity|
|aromatic amino acid transport|
|amino acid import across plasma membrane|
|amino acid import|
|neutral amino acid transport|
|response to exogenous dsRNA|
|catalytic activity|
|L-alpha-amino acid transmembrane transport|
|response to dsRNA|
|L-amino acid transport|
|double-stranded RNA binding|
|amino acid transmembrane transport|
|sodium ion transmembrane transport|
|import across plasma membrane|
|melanosome|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|sodium ion transport|
|calcium ion transport|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|divalent metal ion transport|
|divalent inorganic cation transport|
|cadherin binding|
|apical plasma membrane|
|leukocyte migration|
|monovalent inorganic cation transport|
|organic anion transport|
|carbohydrate metabolic process|
|inorganic cation transmembrane transport|
|anion transport|
|cation transmembrane transport|
|cell surface|
|metal ion transport|
|inorganic ion transmembrane transport|
|import into cell|
|cation transport|
|response to organic cyclic compound|
|ion transmembrane transport|
|cell migration|
|cell motility|
|localization of cell|
|response to nitrogen compound|
|transmembrane transport|
|locomotion|
|ion transport|
|RNA binding|
|movement of cell or subcellular component|
|nitrogen compound transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp292|Menadione 5μM R06 exp292]]|-2.55|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.38|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.26|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.15|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.02|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|-1.84|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.82|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|-1.73|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.7|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|1.73|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|2.02|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2333
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC3A2 Expression in NALM6 Cells: 8.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>