======= SLC7A7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A7
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9056|9056]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UM01|Q9UM01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603593|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L- arginine in monocytes. {ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974, ECO:0000269|PubMed:9878049}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of arginine metabolic process|
|regulation of glutamine family amino acid metabolic process|
|basic amino acid transmembrane transporter activity|
|basic amino acid transmembrane transport|
|basic amino acid transport|
|L-amino acid transmembrane transporter activity|
|L-alpha-amino acid transmembrane transport|
|L-amino acid transport|
|regulation of cellular amino acid metabolic process|
|amino acid transmembrane transport|
|regulation of cellular amine metabolic process|
|amino acid transport|
|organic acid transmembrane transport|
|carboxylic acid transmembrane transport|
|regulation of cellular ketone metabolic process|
|basolateral plasma membrane|
|anion transmembrane transport|
|carboxylic acid transport|
|organic acid transport|
|cellular amino acid metabolic process|
|leukocyte migration|
|regulation of small molecule metabolic process|
|organic anion transport|
|anion transport|
|carboxylic acid metabolic process|
|ion transmembrane transport|
|cell migration|
|oxoacid metabolic process|
|organic acid metabolic process|
|cell motility|
|localization of cell|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|small molecule metabolic process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.81|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.78|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-1.71|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3885
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A7 Expression in NALM6 Cells: 3.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>