======= SLC7A9 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC7A9
  * **<color #00a2e8>Official Name</color>**: solute carrier family 7 member 9
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11136|11136]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P82251|P82251]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC7A9&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC7A9|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604144|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system b(0,+)-like activity). Thought to be responsible for the high- affinity reabsorption of cystine in the kidney tubule. {ECO:0000269|PubMed:10471498, ECO:0000269|PubMed:10588648, ECO:0000269|PubMed:16609684}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|AA permease|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|L-cystine transmembrane transporter activity|
|L-cystine transport|
|sulfur amino acid transport|
|neutral amino acid transmembrane transporter activity|
|L-amino acid transmembrane transporter activity|
|modified amino acid transport|
|peptide antigen binding|
|neutral amino acid transport|
|sulfur compound transport|
|L-alpha-amino acid transmembrane transport|
|brush border membrane|
|L-amino acid transport|
|amino acid transmembrane transport|
|amino acid transport|
|carboxylic acid transmembrane transport|
|organic acid transmembrane transport|
|anion transmembrane transport|
|organic acid transport|
|carboxylic acid transport|
|apical plasma membrane|
|leukocyte migration|
|organic anion transport|
|anion transport|
|ion transmembrane transport|
|cell migration|
|localization of cell|
|cell motility|
|transmembrane transport|
|locomotion|
|ion transport|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|protein-containing complex assembly|
|nitrogen compound transport|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-2.2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6502
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC7A9 Expression in NALM6 Cells: 0.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>