======= SLC8A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLC8A1
  * **<color #00a2e8>Official Name</color>**: solute carrier family 8 member A1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6546|6546]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P32418|P32418]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLC8A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLC8A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/182305|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)- dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Na Ca ex|
|Calx-beta|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration|
|ion antiporter activity involved in regulation of postsynaptic membrane potential|
|calcium:sodium antiporter activity|
|positive regulation of the force of heart contraction|
|relaxation of smooth muscle|
|cellular response to caffeine|
|regulation of postsynaptic cytosolic calcium ion concentration|
|regulation of cell communication by electrical coupling|
|positive regulation of fibroblast migration|
|negative regulation of cytosolic calcium ion concentration|
|relaxation of cardiac muscle|
|sodium ion export across plasma membrane|
|cellular response to purine-containing compound|
|sodium ion import across plasma membrane|
|vascular smooth muscle contraction|
|cell communication by electrical coupling involved in cardiac conduction|
|response to diuretic|
|response to caffeine|
|cellular sodium ion homeostasis|
|membrane depolarization during cardiac muscle cell action potential|
|response to muscle stretch|
|cell communication by electrical coupling|
|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|
|ankyrin binding|
|relaxation of muscle|
|regulation of cardiac muscle contraction by calcium ion signaling|
|response to immobilization stress|
|regulation of the force of heart contraction|
|regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|
|membrane depolarization during action potential|
|regulation of fibroblast migration|
|response to ATP|
|vasoconstriction|
|sodium ion homeostasis|
|cellular response to alkaloid|
|dendritic shaft|
|export across plasma membrane|
|positive regulation of bone mineralization|
|negative regulation of blood vessel diameter|
|calcium ion import|
|T-tubule|
|cell communication involved in cardiac conduction|
|integral component of postsynaptic membrane|
|intercalated disc|
|positive regulation of biomineralization|
|positive regulation of biomineral tissue development|
|cardiac muscle cell action potential|
|membrane depolarization|
|smooth muscle contraction|
|cellular response to cAMP|
|cardiac muscle cell development|
|cardiac cell development|
|regulation of cardiac conduction|
|calcium ion transport into cytosol|
|regulation of bone mineralization|
|inorganic ion import across plasma membrane|
|inorganic cation import across plasma membrane|
|cytoskeletal protein binding|
|regulation of cardiac muscle contraction|
|regulation of release of sequestered calcium ion into cytosol|
|cardiac muscle contraction|
|positive regulation of ossification|
|regulation of sodium ion transport|
|heart contraction|
|cardiac muscle cell differentiation|
|cytosolic calcium ion transport|
|sodium ion transmembrane transport|
|regulation of striated muscle contraction|
|cardiac conduction|
|regulation of biomineralization|
|regulation of biomineral tissue development|
|action potential|
|regulation of heart rate|
|import across plasma membrane|
|regulation of calcium ion transport into cytosol|
|response to cAMP|
|sarcolemma|
|heart process|
|cellular monovalent inorganic cation homeostasis|
|striated muscle contraction|
|response to alkaloid|
|cardiocyte differentiation|
|response to hydrogen peroxide|
|regulation of sequestering of calcium ion|
|ion channel binding|
|Z disc|
|striated muscle cell development|
|multicellular organismal signaling|
|response to organophosphorus|
|response to glucose|
|regulation of blood vessel diameter|
|regulation of tube diameter|
|regulation of tube size|
|monovalent inorganic cation homeostasis|
|response to hexose|
|calcium-mediated signaling|
|regulation of calcium ion transmembrane transport|
|dendritic spine|
|muscle cell development|
|response to monosaccharide|
|response to purine-containing compound|
|sodium ion transport|
|regulation of muscle contraction|
|cardiac muscle tissue development|
|vascular process in circulatory system|
|response to carbohydrate|
|cellular response to xenobiotic stimulus|
|cellular response to hypoxia|
|regulation of ossification|
|response to reactive oxygen species|
|cellular response to decreased oxygen levels|
|calcium ion transmembrane transport|
|striated muscle cell differentiation|
|calmodulin binding|
|response to mechanical stimulus|
|cellular response to oxygen levels|
|response to nutrient|
|regulation of muscle system process|
|regulation of heart contraction|
|muscle cell differentiation|
|regulation of calcium ion transport|
|calcium ion transport|
|muscle contraction|
|telencephalon development|
|positive regulation of cytosolic calcium ion concentration|
|striated muscle tissue development|
|regulation of blood circulation|
|divalent metal ion transport|
|muscle tissue development|
|muscle system process|
|response to xenobiotic stimulus|
|divalent inorganic cation transport|
|response to antibiotic|
|microtubule|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|response to hypoxia|
|response to decreased oxygen levels|
|response to oxygen levels|
|regulation of metal ion transport|
|forebrain development|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|monovalent inorganic cation transport|
|cellular response to drug|
|regulation of membrane potential|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|muscle structure development|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|positive regulation of cell migration|
|response to toxic substance|
|regulation of anatomical structure size|
|positive regulation of cell motility|
|heart development|
|response to extracellular stimulus|
|response to inorganic substance|
|positive regulation of cellular component movement|
|cellular response to organic cyclic compound|
|positive regulation of locomotion|
|cellular metal ion homeostasis|
|inorganic cation transmembrane transport|
|regulation of transmembrane transport|
|regulation of system process|
|cellular response to organonitrogen compound|
|cation transmembrane transport|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|cellular ion homeostasis|
|inorganic ion transmembrane transport|
|cellular response to nitrogen compound|
|import into cell|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|calcium ion binding|
|brain development|
|cellular chemical homeostasis|
|head development|
|ion homeostasis|
|cation transport|
|regulation of cell migration|
|circulatory system development|
|cellular homeostasis|
|regulation of cell motility|
|regulation of cellular localization|
|response to organic cyclic compound|
|ion transmembrane transport|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|response to organonitrogen compound|
|response to drug|
|export from cell|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|response to abiotic stimulus|
|cellular response to endogenous stimulus|
|mitochondrion|
|transmembrane transport|
|positive regulation of developmental process|
|ion transport|
|integral component of plasma membrane|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|tissue development|
|establishment of localization in cell|
|regulation of transport|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5678
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.56 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLC8A1 Expression in NALM6 Cells: 4.56'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>