======= SLIT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: SLIT1
  * **<color #00a2e8>Official Name</color>**: slit guidance ligand 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6585|6585]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75093|O75093]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=SLIT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20SLIT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603742|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LRRNT|
|Laminin G 2|
|EGF|
|LRR 4|
|Laminin G 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dorsal/ventral axon guidance|
|chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration|
|embryonic olfactory bulb interneuron precursor migration|
|negative regulation of synapse assembly|
|tangential migration from the subventricular zone to the olfactory bulb|
|axon extension involved in axon guidance|
|neuron projection extension involved in neuron projection guidance|
|Roundabout binding|
|olfactory bulb interneuron development|
|forebrain morphogenesis|
|substrate-independent telencephalic tangential migration|
|substrate-independent telencephalic tangential interneuron migration|
|olfactory bulb interneuron differentiation|
|retinal ganglion cell axon guidance|
|nuclear migration|
|negative regulation of synapse organization|
|nucleus localization|
|motor neuron axon guidance|
|forebrain neuron development|
|olfactory bulb development|
|olfactory lobe development|
|brain morphogenesis|
|axon extension|
|negative chemotaxis|
|forebrain neuron differentiation|
|telencephalon cell migration|
|neuron projection extension|
|forebrain cell migration|
|forebrain generation of neurons|
|central nervous system neuron development|
|cell|
|developmental cell growth|
|cell growth|
|regulation of synapse assembly|
|developmental growth involved in morphogenesis|
|heparin binding|
|central nervous system neuron differentiation|
|regulation of synapse organization|
|regulation of synapse structure or activity|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|negative regulation of nervous system development|
|establishment of organelle localization|
|axonogenesis|
|forebrain development|
|developmental growth|
|growth|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell part morphogenesis|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|organelle localization|
|neuron projection development|
|negative regulation of cellular component organization|
|calcium ion binding|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|cellular component morphogenesis|
|regulation of nervous system development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|central nervous system development|
|neuron differentiation|
|localization of cell|
|cell motility|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|locomotion|
|intracellular transport|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|neurogenesis|
|cell development|
|establishment of localization in cell|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-2.49|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.13|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.75|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.15|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.456|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6586
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.06 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='SLIT1 Expression in NALM6 Cells: 0.06'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>